Evidence map›Paper›PMID 39901923›Full record

ArticleBrain, behavior, & immunity - health2025

Acute urinary tract infection elicits bladder afferent hypersensitivity.

Harman Sharma, Sarah K Manning, Natalie E Stevens, Georgia Bourlotos, Feargal J Ryan, Cindy Tay, Sonja Klebe, Geraint B Rogers, David J Lynn, Steven L Taylor and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Harman SharmaFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Sarah K ManningMicrobiome and Host Health Programme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
Natalie E StevensFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Georgia BourlotosFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Feargal J RyanFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Cindy TayFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Sonja KlebeDepartment of Anatomical Pathology, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA, 5042, Australia.
Geraint B RogersFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
David J LynnFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Steven L TaylorFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.
Luke GrundyFlinders Health and Medical Research Institute, Flinders University, Bedford Park, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•We explored the neurophysiology underlying painful bladder sensations during UTI.•UTI induces significant bladder afferent hypersensitivity during distension.•Low-threshold afferents elicit exaggerated responses at normal bladder pressures.•Afferent hypersensitivity correlated with the development of bladder dysfunction.•Bladder afferents are key regulators of sensory and behavioural responses to UTI.

Indexed as

AfferentBladderCystitisLower urinary tract symptomsUrinary tract infectionUropathogenic E. coli

Identifiers

PMID39901923
PMCPMC11788684

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.