Evidence map›Paper›PMID 39901871›Full record

ArticlePsychological medicine2025

A longitudinal investigation of the relationship between dimensional psychopathology, gray matter structure, and dementia status in older adulthood.

Nicholas Hoy, Monika Waszczuk, Matthew Sunderland, Samantha J Lynch, Perminder S Sachdev, Henry Brodaty, Simone Reppermund, Louise Mewton

Abstract read
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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas HoyThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.ORCID 0000-0002-5998-6420
Monika WaszczukDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Matthew SunderlandThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.
Samantha J LynchDepartment of Psychiatry, Université de Montréal, Montreal, Canada.
Perminder S SachdevCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Simone ReppermundCentre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Louise MewtonThe Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe structure of psychopathology can be organized hierarchically into a set of transdiagnostic dimensional phenotypes. No studies have examined whether these phenotypes are associated with brain structure or dementia in older adults.

methodsData were drawn from a longitudinal study of older adults aged 70-90 years at baseline (

resultsA higher-order model showed a good fit to the data (BIC = 28,691.85; ssaBIC = 28,396.47; CFI = 0.926; TLI = 0.92; RMSEA = 0.047), including a general factor and lower-order dimensions of internalizing, disinhibited externalizing, and substance use. Baseline symptom dimensions did not predict change over time in total cortical and subcortical GMV or average cortical thickness; regional GMV or cortical thickness in the frontal, parietal, temporal, or occipital lobes; or regional GMV in the hippocampus and cerebellum (all

conclusionsWe found no evidence that transdiagnostic dimensions are associated with gray matter structure or dementia in older adults. Future research should examine these relationships using psychiatric indicators capturing past history of chronic mental illness rather than current symptoms.

Indexed as

Cerebral CortexDementiaGray MatterAgedAged, 80 and overFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaledementia statusgray matter structurelongitudinal analysisolder adulthoodpsychopathologytransdiagnostic dimensions

Identifiers

PMID39901871
PMCPMC11968117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.