Evidence map›Paper›PMID 39901861›Full record

ArticleLab on a chip2025

Large-scale acoustic single cell trapping and selective releasing.

Xiang Zhang, Jacob Smith, Amanda Chengyi Zhou, Jacqueline Thuy-Tram Duong, Tong Qi, Shilin Chen, Yen-Ju Lin, Alexi Gill, Chih-Hui Lo, Neil Y C Lin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiang ZhangDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA. peiyu@g.ucla.edu.ORCID 0000-0001-5954-9821
Jacob SmithDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA. peiyu@g.ucla.edu.
Amanda Chengyi ZhouDepartment of Bioengineering, University of California at Los Angeles, USA.
Jacqueline Thuy-Tram DuongDepartment of Electrical and Computer Engineering, University of California at Los Angeles, USA.
Tong QiDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, USA.
Shilin ChenDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, USA.
Yen-Ju LinDepartment of Electrical and Computer Engineering, University of California at Los Angeles, USA.
Alexi GillDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA. peiyu@g.ucla.edu.
Chih-Hui LoDepartment of Bioengineering, University of California at Los Angeles, USA.
Neil Y C LinDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA. peiyu@g.ucla.edu.
Jing WenDepartment of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California at Los Angeles, USA.
Yunfeng LuDepartment of Chemical and Biomolecular Engineering, University of California at Los Angeles, USA.ORCID 0000-0002-8589-0297
Pei-Yu ChiouDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, USA. peiyu@g.ucla.edu.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
SPOTs: Optical Technologies for Instantly Quantifying Multicellular Response ProfilesR01GM127985 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIOU, PEI-YU, TEITELL, MICHAEL A · 2020 to 2023
$1.7M
NCI NIH HHS P30 CA016042NIGMS NIH HHS R01 GM127985NSF CMMI 2029454NSF DBI 2345571
6 · The paper itself

Abstract

Recent advancements in single-cell analysis have underscored the need for precise isolation and manipulation of individual cells. Traditional techniques for single-cell manipulation are often limited by the number of cells that can be parallel trapped and processed and usually require complex devices or instruments to operate. Here, we introduce an acoustic microfluidic platform that efficiently traps and selectively releases individual cells using spherical air cavities embedded in a polydimethylsiloxane (PDMS) substrate for large scale manipulation. Our device utilizes the principle of acoustic impedance mismatches to generate near-field acoustic potential gradients that create trapping sites for single cells. These single cell traps can be selectively disabled by illuminating a near-infrared laser pulse, allowing targeted release of trapped cells. This method ensures minimal impact on cell viability and proliferation, making it ideal for downstream single-cell analysis. Experimental results demonstrate our platform's capability to trap and release synthetic microparticles and biological cells with high efficiency and biocompatibility. Our device can handle a wide range of cell sizes (8-30 μm) across a large active manipulation area of 1 cm

Indexed as

AcousticsLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesSingle-Cell AnalysisAnimalsDimethylpolysiloxanesEquipment DesignHumansbaysilonDimethylpolysiloxanes

Identifiers

PMID39901861
PMCPMC12335873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.