Evidence map›Paper›PMID 39901684›Full record

ArticleCurrent cancer drug targets2026

Influence of DNA Copy Number Aberrations in ABC Transporter Family Genes on the Survival of Patients with Primary Operatable Non-Small Cell Lung Cancer.

Matvey Mikhailovich Tsyganov, Marina Konstantinovna Ibragimova, Evgeny Olegovich Rodionov, Anastavia Alekseevna Frolova, Irina Aleksandrovna Tsydenova, Elizaveta Andreevna Lutzkaya, Sergey Viktorovich Miller

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Article in Current cancer drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matvey Mikhailovich TsyganovCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0001-7419-4512
Marina Konstantinovna IbragimovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0001-8815-2786
Evgeny Olegovich RodionovCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0003-4980-8986
Anastavia Alekseevna FrolovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0003-3297-1680
Irina Aleksandrovna TsydenovaCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0002-2716-3075
Elizaveta Andreevna LutzkayaFederal State Budgetary Educational Institution of Higher Education Saint-Petersburg State University, Universitetskaya Embankment, 7/9, St. Petersburg, Russian Federation.ORCID 0009-0004-2291-2307
Sergey Viktorovich MillerCancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; 5, Kooperativny Street, Tomsk, Russian Federation.ORCID 0000-0002-5365-9840

Funding

Russian Science Foundation 22-15-00169
6 · The paper itself

Abstract

purposePrevious research has shown, that ABC transporters gene expression level can predict the efficacy of therapy. However, other mechanisms of gene activity are rarely considered, especially in non-small cell lung cancer (NSCLC). Thus, the purpose of the work was to assess chromosomal aberrations of all 49 ABC transporters genes and the expression levels of some ABC genes, as well as their correlation with survival. MATERIALS AND

methodsThe surgical material of 104 patients with NSCLC was used in this study. Treatment included surgery and 3 courses of adjuvant chemotherapy with "platinum doublets". DNA and RNA were isolated from the samples, followed by microarray analysis to assess the expression and chromosomal aberrations (deletions and amplifications) of ABC genes.

resultsMetastatic-free survival (MFS) was higher with

conclusionThus, not only expression but also chromosomal aberrations were found to be associated with patient survival. These findings could be a potential marker of metastatic-free survival.

Indexed as

ATP-Binding Cassette TransportersCarcinoma, Non-Small-Cell LungDNA Copy Number VariationsLung NeoplasmsAdultAgedATP-Binding Cassette, Sub-Family C ProteinsFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMultidrug Resistance-Associated Protein 2ABCC2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP-Binding Cassette Transportersmultidrug resistance-associated protein 1Multidrug Resistance-Associated Protein 2ABC transportersadjuvant chemotherapyDNA copy number aberrationsgene expressionmetastasis-free survivalNon-small cell lung cancer

Identifiers

PMID39901684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.