ArticleCurrent medicinal chemistry2025
Synthesis, Anticancer Activity, and Mitochondria-targeted Bioimaging Applications of Novel Fluorescent Calix [4]arenes-benzimidazole Derivatives.
Article in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- The Synergy of Macrocycles and Heterocycles: A Review of Coordination Behavior, Sensing, and Functional Materials Based on Calixarenes.Molecules (Basel, Switzerland) · 2026Review
- A calixarene-BODIPY fluorescent sensor for selective FeRSC advances · 2026Article
- Recent Advances in the Application of Mitochondria-targeted Fluorescent Probes.Current medicinal chemistry · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundCalix[n]arenes have attracted great attention due to their biocompatibility and superior stability. When the necessary functional groups are attached to these compounds, they may have the potential to target tumor tissues. Benzimidazoles are among the anticancer drugs discovered in recent years.
aimThe aim of this study was to design and synthesise a series of calix[4]arenes-benzimidazoles. For comparison purposes, a benzimidazole derivative was synthesized by attaching it to the diester. The anticancer effects of these compounds were investigated by performing cell proliferation, apoptosis, and cell imaging studies on cancer cell lines.
methodsSome of the obtained compounds were synthesized by employing the methods available in literature studies, and the rest were synthesized by modifying previous methods. As a result, a total of 3 new fluorescent calix[4]arene-benzimidazole derivatives were synthesized. MTT was used for cell proliferation, and Annexin V was used for apoptosis studies. For confocal imaging studies, cells were treated with DAPI and Mito- Tracker dyes.
resultsFour designed calix[4]arene-benzimidazoles were successfully synthesized and structurally confirmed by 1H-NMR, 13C-NMR, and IR spectroscopy. The anticancer study on four synthesized compounds was performed. Bio-imaging studies were performed using confocal microscopy for the three successfully synthesized fluorescent compounds.
conclusionCB5-a and CB5-c were found to be the most effective against MCF-7 cells and CB5-b against HT-29 cells in the MTT test. Apoptosis analyses also proved that these compounds inhibited the proliferation of cancer cells. As a comparison compound, the synthesized CB5-R proved to be less cytotoxic than the fluorescent compounds by the MTT method, and we found the cationic compound to bind to the calix[4]arene more effectively than the molecule's binding to the diester.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.