Evidence map›Paper›PMID 39901538›Full record

ReviewAnti-cancer agents in medicinal chemistry2025

Precision Therapy for Prostate Cancer: Advancements in Polymeric Nanocarrier Systems.

Lalit Kumar, Ritesh Rana, Nusrat K Shaikh, Sumit Kumar, Vikas Aggarwal, Komal Komal, Vuluchala Jyothiraditya

Abstract readReview
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In one paragraph

Review in Anti-cancer agents in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lalit KumarDepartment of Pharmaceutics, GNA School of Pharmacy, GNA University, Phagwara, Punjab, 144401, India.
Ritesh RanaDepartment of Pharmaceutical Sciences (Pharmaceutics), Himachal Institute of Pharmaceutical Education and Research (HIPER), Bela-Nadaun, District- Hamirpur, H.P, 177033, India.
Nusrat K ShaikhDepartment of Quality Assurance, Smt. N. M. Padalia Pharmacy College, Ahmedabad, 382210, Gujarat, India.
Sumit KumarDepartment of Pharmaceutical Chemistry, Himachal Institute of Pharmaceutical Education and Research (HIPER), Bela-Nadaun, District- Hamirpur, H.P, 177033, India.
Vikas AggarwalSenior Pharmacovigilance Specialist, Continuum India LLP, 3rd Floor, Tower F DLF Building, Chandigarh Technology Park, Chandigarh, 160101, India.
Komal KomalDepartment of Pharmacology, Chandigarh College of Pharmacy, Landran, Sahibzada Ajit Singh Nagar, Punjab, 140307, India.
Vuluchala JyothiradityaCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602105, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionProstate cancer is a major worldwide health concern, and existing treatments often face challenges such as drug resistance, systemic toxicity, and insufficient targeting. Polymeric nanocarriers are currently employed as sophisticated tools in the field of oncology, offering the possibility to augment the administration and efficacy of anticancer therapies. In order to effectively eradicate prostate cancer, this review delves into the function of polymeric nanocarriers.

methodsDatabases such as PubMed, ScienceDirect, and Google Scholar were utilized to do a comprehensive literature assessment. For this search, we used terms like "polymeric nanocarriers," "prostate cancer," "drug delivery," and "nanotechnology."

resultsStudies have shown that polymeric nanocarriers greatly improve the delivery and effectiveness of treatments for prostate cancer. Nanocarriers enhance the solubility, stability, and bioavailability of drugs, resulting in improved therapeutic effects. Functionalization using targeting ligands, such as folic acid and prostate-specific membrane antigen (PSMA) antibodies, has demonstrated the ability to enhance targeted specificity, resulting in a decrease in off-target effects and systemic toxicity. Polymeric nanocarriers facilitate precise and prolonged drug delivery, leading to elevated drug levels in tumor tissues.

conclusionPolymeric nanocarriers are a notable breakthrough in the management of prostate cancer, providing precise medication administration, decreased toxicity, and improved therapy effectiveness. However, additional study is necessary to enhance the design of nanocarriers, evaluate their long-term safety, and enable their use in clinical applications. Continued interdisciplinary research and collaboration are essential for addressing current obstacles and maximizing the promise of polymeric nanocarriers in the treatment of prostate cancer.

Indexed as

Antineoplastic AgentsDrug CarriersNanoparticlesPolymersPrecision MedicineProstatic NeoplasmsAnimalsDrug Delivery SystemsHumansMaleAntineoplastic AgentsDrug CarriersPolymersFunctionalizationpolymeric nanocarriersprostate cancerprostate-specific membrane antigen (PSMA).systemic toxicitytargeting

Identifiers

PMID39901538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.