Evidence map›Paper›PMID 39901164›Full record

ArticleBMC medicine2025

Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy.

Erin L Fee, Haruo Usuda, Sean W D Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W Clarke, Demelza J Ireland, John P Newnham and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Erin L FeeDivision of Obstetrics and Gynecology, Medical School, The University of Western Australia, Perth, WA, Australia. erin.fee@uwa.edu.au.
Haruo UsudaDivision of Obstetrics and Gynecology, Medical School, The University of Western Australia, Perth, WA, Australia.
Sean W D CarterDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Hideyuki IkedaCentre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Tsukasa TakahashiCentre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Yuki TakahashiCentre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Yusaku KumagaiCentre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.
Michael W ClarkeSchool of Biomedical Sciences, The University of Western Australia, Perth, WA, Australia.
Demelza J IrelandDivision of Obstetrics and Gynecology, Medical School, The University of Western Australia, Perth, WA, Australia.
John P NewnhamDivision of Obstetrics and Gynecology, Medical School, The University of Western Australia, Perth, WA, Australia.
Masatoshi SaitoDivision of Obstetrics and Gynecology, Medical School, The University of Western Australia, Perth, WA, Australia.
Sebastian E IllanesDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Binny Priya SesurajanDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Liang ShenBiostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mahesh A ChoolaniDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Gokce OguzGenome Institute of Singapore. Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore, Singapore.
Adaikalavan RamasamyDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sara RitchieA8, Darkan, WA, Australia.
Andrew RitchieA8, Darkan, WA, Australia.
Alan H JobeCincinnati Children's Hospital Medical Centre, University of Cincinnati School of Medicine, Cincinnati, OH, USA.
Matthew W KempCentre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntenatal steroid (ANS) therapy is given to women at risk of preterm delivery to accelerate fetal lung maturation. However, the benefit of ANS therapy is variable and how maternal and fetal factors contribute to this observed variability is unknown. We aimed to test the degree of concordance in preterm lung function, and correlate this with genomic, transcriptomic, and pharmacokinetic variables in preterm dizygotic twin ovine fetuses.

methodsThirty-one date-mated ewes carrying twin fetuses at 123 ± 1 days' gestation received maternal intramuscular injections of either (i) 1 × 0.25 mg/kg betamethasone phosphate and acetate (CS1, n = 11 twin pairs) or (ii) 2 × 0.25 mg/kg betamethasone phosphate and acetate, 24 h apart (CS2, n = 10 twin pairs) or (iii) 2 × saline, 24 h apart (negative control, n = 10 twin pairs). Fetuses were surgically delivered 24 h after their final treatment and ventilated for 30 min.

resultsANS-exposed female fetuses had lower arterial partial pressure of carbon dioxide (PaCO

conclusionsTwin fetal responses and ANS tissue levels were comparable with those from singleton fetuses in earlier studies. Twin ovine fetuses thus benefit from ANS in a similar manner to singleton fetuses, and a larger dose of betamethasone is not required. Assuming no difference in input from the placental or maternal compartments, fetal lung responses to ANS therapy in dizygotic twin preterm lambs are dependent on the fetus itself. These data suggest a potential heritable role in determining ANS responsiveness.

Indexed as

BetamethasoneFetusGlucocorticoidsPolymorphism, Single NucleotideTwins, DizygoticAnimalsFemaleLungMalePregnancySheepBetamethasoneGlucocorticoidsAntenatal steroidsBetamethasoneFetusFraternal twinsGlucocorticoidsLung maturationPreterm birthSheep

Identifiers

PMID39901164
PMCPMC11792249

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.