Evidence map›Paper›PMID 39901105›Full record

ArticleBMC infectious diseases2025

More than meets the eye: Nocardia farcinica, Candida dubliniensis and Aspergillus spp. co-infection in a patient with multiple myeloma treated with multiple treatment regimens.

Lotte Vrijders, Erwin Ho, Danielle Van der Beek, Inge Vrelust, Heleen Nailis

Abstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lotte VrijdersDepartment of Haematology, AZ Turnhout Hospital, Turnhout, Belgium. lotte.vrijders@student.kuleuven.be.
Erwin HoDepartment of Medical Microbiology, AZ Turnhout Hospital, Turnhout, Belgium.
Danielle Van der BeekDepartment of Medical Microbiology, AZ Turnhout Hospital, Turnhout, Belgium.
Inge VrelustDepartment of Haematology, AZ Turnhout Hospital, Turnhout, Belgium.
Heleen NailisDepartment of Medical Microbiology, AZ Turnhout Hospital, Turnhout, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive infections by Nocardia farcinica, Aspergillus species (spp.) and Candida dubliniensis are rare infectious complications in patients diagnosed with multiple myeloma. CASE PRESENTATION: In this case report, we describe a patient who received three lines of therapy, with proteasome inhibitors, corticosteroids, cyclophosphamide and lenalidomide, and who was concurrently infected with these three opportunistic pathogens. A blood stream infection with C. dubliniensis was treated with 4 weeks of anidulafungin. Aspergillus spp. was treated for 12 weeks with voriconazole. N. farcinica treatment was continued indefinitely with co-trimoxazole and moxifloxacin after regression at discharge of brain abscesses and the pulmonary aspergilloma.

conclusionThe diagnostic challenges and management in this particularly vulnerable patient are highlighted.

Indexed as

AspergillosisCandidiasisCoinfectionMultiple MyelomaNocardia InfectionsAntifungal AgentsAspergillusCandidaHumansNocardiaAntifungal AgentsBrain abscessCandida dubliniensisInvasive aspergillosisMultiple myelomaN. farcinica

Identifiers

PMID39901105
PMCPMC11789363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.