Evidence map›Paper›PMID 39900887›Full record

ArticleJournal of cardiovascular translational research2025

Lymphatic Drainage in Patients with Heart Failure: A Feasibility Study.

Husam M Salah, Adrian Ebner, Ravi N Srinivasa, Waleska Pabon-Ramos, Jeffrey Forris Beecham Chick, Jan Biegus, Piotr Ponikowski, Abubaker Khalifa, Marat Fudim

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Husam M SalahDivision of Cardiology, Department of Medicine, Duke University, Durham, NC, USA.
Adrian EbnerCardiovascular Department, Sanatorio Italiano, Asunción, Paraguay.
Ravi N SrinivasaDivision of Vascular and Interventional Radiology, Department of Radiology, University of California Los Angeles, Los Angeles, CA, USA.
Waleska Pabon-RamosDivision of Interventional Radiology, Department of Radiology, Duke University, Durham, NC, USA.
Jeffrey Forris Beecham ChickDepartment of Radiology, Section of Vascular and Interventional Radiology, University of Washington, Seattle, WA, USA.
Jan BiegusInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Piotr PonikowskiInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Abubaker KhalifaDivision of Critical Care Medicine, Joseph Brant Hospital, McMaster University, Hamilton, ON, Canada.
Marat FudimDivision of Cardiology, Department of Medicine, Duke University, Durham, NC, USA. marat.fudim@gmail.com.ORCID 0000-0002-8671-7007

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphatic dysfunction contributes to congestion and end-organ damage in heart failure (HF), yet current therapies do not directly target lymphatic congestion. Thoracic duct (TD) drainage offers a novel approach to address this gap. This multicenter feasibility study evaluated the safety and feasibility of minimally invasive TD drainage in patients with HF. Four patients with New York Heart Association class II-IV HF and fluid overload underwent fluoroscopy-guided TD access via cervical, abdominal, or transvenous brachial approaches. Lymph was drained by gravity for up to 3 hours, and hemodynamic changes were measured. TD drainage was successful in all patients, with a mean lymph output of 430 mL. Mean reductions in right atrial and pulmonary capillary wedge pressures were 4 mmHg and 1.5 mmHg, respectively. No major adverse events occurred. TD drainage appears feasible and safe, with potential decongestive benefits. Larger studies are needed to confirm its role in HF management.

Indexed as

DrainageHeart FailureLymphThoracic DuctAgedFeasibility StudiesFemaleHemodynamicsHumansMaleMiddle AgedPulmonary Wedge PressureTime FactorsTreatment OutcomeCongestionHeart failureInterventionalLymphatic

Identifiers

PMID39900887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.