Evidence map›Paper›PMID 39900879›Full record

ArticleProbiotics and antimicrobial proteins2025

Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response.

Doaa Ibrahim, Safaa I Khater, Hoda S Sherkawy, Aya Elgamal, Asmaa A Hasan, Asmaa A Muhammed, Mohamed F M Farag, Samar A Eissa, Tamer Ahmed Ismail, Hemmat M Eissa and 3 more

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Double-layer microencapsulation ofBiotechnology reports (Amsterdam, Netherlands) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Doaa IbrahimDepartment of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. doibrahim@vet.zu.edu.eg.
Safaa I KhaterDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Hoda S SherkawyDepartment of Medical Biochemistry, Faculty of Medicine, Aswan University, Aswan, Egypt.
Aya ElgamalDepartment of Animal Histology and Anatomy, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Cairo, Egypt.
Asmaa A HasanDepartment of Human Anatomy and Embryology, Faculty of Medicine, Aswan University, Aswan, Egypt.
Asmaa A MuhammedDepartment of Medical Physiology, Faculty of Medicine, Aswan University, Aswan, 81511, Egypt.
Mohamed F M FaragDepartment of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Samar A EissaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Kafrelsheikh University, Kafr El-Sheikh, Egypt.
Tamer Ahmed IsmailDepartment of Clinical Laboratory Sciences, Turabah University College, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
Hemmat M EissaDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Areej A EskandraniChemistry Department, College of Science, Taibah University, Medina, Saudi Arabia.
Wafa S AlansariBiochemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Mahran Mohamed Abd El-EmamDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel disease (IBD), also known as ulcerative colitis and Crohn's disease, is a chronic inflammatory disorder affecting millions of people worldwide. Herein, nano-encapsulated multi-strain probiotics formulation, comprising Bifidobacterium breve DSM24732 and B. coagulans SANK 70258 and L. plantarum DSM24730 (BBLNPs) is used as an effective intervention technique for attenuating IBD through gut microenvironment regulation. The efficacy of the prophylactic role of BBLNPs in alleviating injury induced by dextran sulfate sodium (DSS) was evaluated by assessing oxidative and inflammatory responses, levels of short-chain fatty acids (SCFAs) and their regulation on GPR41/43 pathway, expression of genes related to tight-junctions and autophagy, immunohistochemistry of IL1β and GPR43, and histological examination of inflamed colonic tissue. The severity of clinical signs and paracellular permeability to FITC (fluorescein isothiocyanate)-labeled dextran was significantly decreased after BBLNP treatment. Reduction of oxidative stress-associated biomarkers (MDA, ROS, and H

Indexed as

Bifidobacterium breveColitisFatty Acids, VolatileLactiplantibacillus plantarumProbioticsAnimalsColonDextran SulfateDisease Models, AnimalMaleOxidative StressRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledDextran SulfateFatty Acids, VolatileReceptors, G-Protein-CoupledAutophagyColitisNano-deliveryOxidant-antioxidant levelProbioticShort-chain fatty acid

Identifiers

PMID39900879

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.