ArticleCommunications biology2025
The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The relationship between depression and cognitive function among adults with spinal cord injury: a systematic review and meta-analysis.Spinal cord · 2026Pooled it
- Multimodal MRI local metrics and cognitive performance following water intake in 12-h water-restricted adults: a randomized controlled trial.Frontiers in nutrition · 2026Trial
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- The Orbitofrontal Cortex Represents the Allocentric Spatial States of Dynamic Agents Within a Static Environmental Framework.Neuroscience bulletin · 2026Article
- Article
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.The European journal of neuroscience · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer's disease.Translational neurodegeneration · 2025Review
- Predictive encoding of auditory sequences in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
A cognitive map is an internal model of the world's causal structure, crucial for adaptive behaviors. The orbitofrontal cortex (OFC) is central node to decision-making and cognitive map representation. However, it remains unclear how the medial OFC (mOFC) and lateral OFC (lOFC) contribute to the formation of cognitive maps in humans. By performing a multi-step sequential task and multivariate analyses of functional magnetic resonance imaging (fMRI) data, we found that the mOFC and lOFC play complementary but dissociable roles in this process. Specifically, the mOFC represents all hidden task state components. The lOFC and dorsolateral prefrontal cortex (dlPFC) encode abstract rules governing structure knowledge across task states. Furthermore, the two orbitofrontal subregions are functionally connected to share state-hidden information for constructing a representation of the task structure. Collectively, these findings provide an account that can increase our understanding of how the brain constructs abstract cognitive maps in a task-relevant space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.