ArticleArchives of toxicology2025
Exposure to polystyrene nanoplastics induces lysosomal enlargement and lipid droplet accumulation in KGN human ovarian granulosa cells.
Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Lipidomic Remodeling by HILPDA in Granulosa Cells Impairs Ovarian Reserve Through Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Ovarian toxic effects of micro- and nanoplastics (Review).Experimental and therapeutic medicine · 2026Review
- Nanoplastics Impair Neuroimmune Integrity Via Cellular Retention and Multiple Organelle Stress.Journal of hazardous materials advances · 2026Article
- Harmful Effects of Microplastics and Nanoplastics in Human Body Systems: A Systematic Review.Diseases (Basel, Switzerland) · 2026Review
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Polystyrene and polyethylene terephthalate nanoplastics differentially impact mouse ovarian follicle function.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Given the ubiquitous presence of plastic products in daily life, human exposure to nanoplastics (NPs) is inevitable. Previous studies have suggested that exposure to polystyrene nanoplastics (PSNPs) may contribute to reproductive disorders; however, the underlying mechanism remains elusive. The goal of this study was to investigate the impact of PSNPs on KGN human ovarian granulosa cells. KGN cells were exposed to varying concentrations of PSNPs (0-400 μg/mL) for 48 h; alterations in cell survival and morphology were assessed to elucidate potential toxic effects. PSNPs were shown to enter KGN cells. Exposure to PSNPs did not induce significant changes in cytotoxicity, Calcein intensity, or active mitochondria levels in KGN cells. However, PSNP exposure did induce a dose-dependent increase in cytoplasmic vacuoles and an increase in total lysosome area and in the numbers of lipid droplets in KGN cells. Our findings provide compelling evidence that PSNPs can penetrate cell cytoplasm and induce toxicity, resulting in an elevation in the numbers of lysosomes and lipid droplets. This may represent one mechanism by which PSNPs exert damage on the reproductive system.
Indexed as
Identifiers
39900702What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.