Evidence map›Paper›PMID 39900594›Full record

ArticleScientific reports2025

Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system.

Niklas B Steuer, Hannah Lüken, Peter C Schlanstein, Matthias F Menne, Christiane Hoffmann, Cavan Lübke, Thomas Schmitz-Rode, Sebastian Victor Jansen, Ulrich Steinseifer, Rüdger Kopp

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niklas B SteuerDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Hannah LükenDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Peter C SchlansteinDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Matthias F MenneDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Christiane HoffmannDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Cavan LübkeDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.
Thomas Schmitz-RodeInstitute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Pauwelsstraße 20, 52074, Aachen, Germany.
Sebastian Victor JansenDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany. jansen@ame.rwth-aachen.de.
Ulrich SteinseiferDepartment of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Rüdger KoppDepartment of Intensive Care Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbon monoxide (CO) poisoning is one of the most common causes of injury and death from poisoning. The primary objective of therapy is to eliminate CO from the patient as quickly as possible to prevent acute and long-term effects. The ideal treatment is hyperbaric oxygen in a pressure chamber. However, pressure chambers are scarce, and therefore, the most common treatment is normobaric oxygen (NBO), which, however, has limited efficacy. Here, we present a full-scale batch system for extracorporeal hyperoxygenation therapy (EHT), which facilitates CO elimination extracorporeally by increasing the dissolved oxygen concentration in the blood. The EHT was characterized in vitro, resulting in a minimum carboxyhemoglobin half-life of 3.26 ± 0.11 min. In large animal trials the EHT reduced the median carboxyhemoglobin half-life by 42% (29.77 min EHT vs. 70.8 min control (NBO)). However, the EHT also induced oscillations in hemodynamic pressures due to changes in the animals' circulatory volume during operation. After optimization, the EHT could be a promising option for treating CO poisoning.

Indexed as

Carbon Monoxide PoisoningExtracorporeal Membrane OxygenationHyperbaric OxygenationOxygenAnimalsCarboxyhemoglobinFeasibility StudiesHalf-LifeMaleCarboxyhemoglobinOxygen

Identifiers

PMID39900594
PMCPMC11790865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.