Evidence map›Paper›PMID 39900593›Full record

ArticleNature communications2025

Structural basis of SIRT7 nucleosome engagement and substrate specificity.

Carlos Moreno-Yruela, Babatunde E Ekundayo, Polina N Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. A Chromatin Biology Assessment of AlphaFold3.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Structural and enzymatic plasticity of SIRT6 deacylase activity.The Journal of biological chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carlos Moreno-Yruela *Laboratory of Biophysical Chemistry of Macromolecules (LCBM), Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland. carlos.morenoyruela@epfl.ch.ORCID http://orcid.org/0000-0003-2450-6519
Babatunde E Ekundayo *Laboratory of Biological Electron Microscopy (LBEM), Institute of Physics (IPHYS), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-0928-4682
Polina N FotevaLaboratory of Biophysical Chemistry of Macromolecules (LCBM), Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0009-0001-9338-8985
Dongchun NiLaboratory of Biological Electron Microscopy (LBEM), Institute of Physics (IPHYS), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-3193-6077
Esther Calvino-SanlesLaboratory of Biophysical Chemistry of Macromolecules (LCBM), Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6400-3126
Henning StahlbergLaboratory of Biological Electron Microscopy (LBEM), Institute of Physics (IPHYS), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-1185-4592
Beat FierzLaboratory of Biophysical Chemistry of Macromolecules (LCBM), Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences (SB), EPFL, Lausanne, Switzerland. beat.fierz@epfl.ch.ORCID http://orcid.org/0000-0002-2991-3044

Funding

'la Caixa' Foundation (Caixa Foundation) ID 100010434, fellowship LCF/BQ/EU22/11930058Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_200604Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) IZLCZO_206089
6 · The paper itself

Abstract

Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD

Indexed as

NucleosomesSirtuinsAcetylationCatalytic DomainCryoelectron MicroscopyDNAHistonesHumansLysineModels, MolecularProtein BindingSubstrate SpecificityDNAHistonesLysineNucleosomesSIRT7 protein, humanSirtuins

Identifiers

PMID39900593
PMCPMC11790868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.