ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence.
Adrienne Y Jo, Yihan Xie, Lisa M Wooldridge, Sophie A Rogers, Blake A Kimmey, Amrith Rodrigues, Raquel Adaia Sandoval Ortega, Kate Townsend Creasy, Kevin T Beier, Julie A Blendy and 1 more
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Adrienne Y JoDepartments of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Yihan XieDepartments of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104.ORCID 0009-0002-3084-3204
Lisa M WooldridgePsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Sophie A RogersPsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Blake A KimmeyPsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Amrith RodriguesTranslational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Raquel Adaia Sandoval OrtegaPsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Kate Townsend CreasyTranslational Medicine and Human Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Kevin T BeierDepartment of Physiology and Biophysics, Neurobiology and Behavior, Biomedical Engineering, Pharmaceutical Sciences, Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697.ORCID 0000-0002-4934-1338
Julie A BlendyDepartments of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 blendy@pennmedicine.upenn.edu gcorder@upenn.edu.ORCID 0000-0003-1705-9001
Gregory CorderPsychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 blendy@pennmedicine.upenn.edu gcorder@upenn.edu.
Funding
T32 Translational Addiction Research Fellowship ProgramT32DA028874 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Julie A Blendy, Anna Rose Childress · 2010 to 2026
$5.0M
Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8M
Harnessing cortical neuromodulation to disrupt pain perceptionDP2GM140923 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CORDER, GREGORY · 2020 to 2022
$2.6M
Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
Opioids initiate dynamic maladaptation in brain reward and affect circuits that occur throughout chronic exposure and withdrawal that persist beyond cessation. Protracted abstinence is characterized by negative affective behaviors such as heightened anxiety, irritability, dysphoria, and anhedonia, which pose a significant risk factor for relapse. While the ventral tegmental area (VTA) and μ-opioid receptors (MORs) are critical for opioid reinforcement, the specific contributions of VTA
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence. · full record | OpenQuestion