Evidence map›Paper›PMID 39900471›Full record

ReviewFEMS microbiology reviews2025

Microbial engineering for monocyclic aromatic compounds production.

Guipeng Hu, Cong Gao, Xiaomin Li, Wei Song, Jing Wu

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guipeng HuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.ORCID 0009-0008-3625-6266
Cong GaoSchool of Biotechnology, Jiangnan University, Wuxi 214122, China.
Xiaomin LiSchool of Biotechnology, Jiangnan University, Wuxi 214122, China.
Wei SongSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
Jing WuSchool of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.

Funding

National Key Research and Development Program of China 2021YFC2103100National Natural Science Foundation of China 22478158Natural Science Foundation of Jiangsu Province BK20220022
6 · The paper itself

Abstract

Aromatic compounds serve pivotal roles in plant physiology and exhibit antioxidative and antimicrobial properties, leading to their widespread application, such as in food preservation and pharmaceuticals. However, direct plant extraction and petrochemical synthesis often struggle to meet current needs due to low yield or facing economic and environmental hurdles. In the past decades, systems metabolic engineering enabled eco-friendly production of various aromatic compounds, with some reaching industrial levels. In this review, we highlight monocyclic aromatic chemicals, which have relatively simple structures and are currently the primary focus of microbial synthesis research. We then discuss systems metabolic engineering at the enzyme, pathway, cellular, and bioprocess levels to improve the production of these chemicals. Finally, we overview the current limitations and potential resolution strategies, aiming to provide reference for future studies on the biosynthesis of aromatic products.

Indexed as

BacteriaHydrocarbons, AromaticMetabolic EngineeringHydrocarbons, Aromaticaromatic compoundsindustrial biotechnologymetabolic engineeringmicrobial productionpathway optimizationsynthetic biology

Identifiers

PMID39900471
PMCPMC11837758

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.