Evidence map›Paper›PMID 39900383›Full record

ArticleClinical genetics2025

Digenic Inheritance of Monoallelic MUTYH and POLE Germline Variants in Adrenocortical Carcinoma: Implications for Tumorigenesis and Immunotherapy.

Jonathan Lopez, Adrien Buisson, Adel Ounnas, Gaelle Tachon, Alain Viari, Florence De Fraipont, Juliette Albuisson, Marc Barritault, Pierre-Paul Bringuier, Jean-Paul Feugeas and 2 more

Abstract readCase Reports
In one paragraph

Article in Clinical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan LopezGCS AURAGEN, Lyon, France.
Adrien BuissonGCS AURAGEN, Lyon, France.
Adel OunnasGCS AURAGEN, Lyon, France.
Gaelle TachonGCS AURAGEN, Lyon, France.
Alain ViariGCS AURAGEN, Lyon, France.
Florence De FraipontGCS AURAGEN, Lyon, France.
Juliette AlbuissonGCS AURAGEN, Lyon, France.
Marc BarritaultGCS AURAGEN, Lyon, France.
Pierre-Paul BringuierGCS AURAGEN, Lyon, France.
Jean-Paul FeugeasGCS AURAGEN, Lyon, France.
Anne Mc LeerGCS AURAGEN, Lyon, France.
Ahmed BourasGCS AURAGEN, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collision of monoallelic MUTYH and POLE germline variants in a patient with adrenocortical carcinoma who achieved a strong response to immunotherapy.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaDNA GlycosylasesGerm-Line MutationPoly-ADP-Ribose Binding ProteinsAgedAllelesCarcinogenesisGenetic Predisposition to DiseaseHumansImmunotherapyDNA GlycosylasesmutY adenine glycosylasePoly-ADP-Ribose Binding Proteinsadrenocortical carcinomadigenic inheritanceimmunotherapyMUTYHPOLE

Identifiers

PMID39900383
PMCPMC12050244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.