Evidence map›Paper›PMID 39900372›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal-Adhesive Photoreactive Hydrogel.

Wen Wu, Jian Zhang, Xiao Qu, Ting Chen, Jinming Li, Yongzhi Yang, Lifeng Chen, Alex Hoover, Fanying Guo, Cheng Kong and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wen WuDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.
Jian ZhangBen May Department for Cancer Research, University of Chicago, GCIS W408B, 929 E 57th Street, Chicago, IL, 60637, USA.
Xiao QuDepartment of Endoscopy, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Shanghai, 200032, China.
Ting ChenSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China.
Jinming LiDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.
Yongzhi YangDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.
Lifeng ChenBen May Department for Cancer Research, University of Chicago, GCIS W408B, 929 E 57th Street, Chicago, IL, 60637, USA.
Alex HooverBen May Department for Cancer Research, University of Chicago, GCIS W408B, 929 E 57th Street, Chicago, IL, 60637, USA.
Fanying GuoDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.
Cheng KongDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.
Bingkun BaoSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China.
Qiuning LinSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China.
Mengxin ZhouSchool of Chemistry and Molecular Engineering, East China University of Science and Technology, No.130 Meilong Road, Shanghai, 200237, China.
Linyong ZhuSchool of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai, 200240, China.
Xiaoyang WuBen May Department for Cancer Research, University of Chicago, GCIS W408B, 929 E 57th Street, Chicago, IL, 60637, USA.ORCID https://orcid.org/0000-0001-6378-3207
Yanlei MaDepartment of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dongan Road, Shanghai, 200032, China.

Funding

Histone lactylation pathway in hair cycle: deacylases and their protein targetsR01AR078555 · NIAMS · UNIVERSITY OF CHICAGO · PI LIN, HENING, ZHAO, YINGMING · 2021 to 2025
$3.3M
Development of epidermal progenitor cell-based therapy for regenerative medicineR01OD023700 · OD · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG · 2017 to 2021
$2.4M
A cutaneous gene therapy for cocaine abuse and alcohol co-abuseR01DA047785 · NIDA · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG, XU, MING · 2019 to 2023
$2.2M
Development of a novel lymphocyte engineering approach for treatment of vitiligoR21AR080761 · NIAMS · UNIVERSITY OF CHICAGO · PI WU, XIAOYANG · 2022 to 2023
$397k
Alan B. Slifka Foundation and Israel Cancer Fund for Pediatric Sarcoma GrantCancer Immunotherapy Team Science AwardCancer Research Institute (CRI) Technology Impact AwardNIAMS NIH HHS R01 AR078555NIAMS NIH HHS R21 AR080761NIDA NIH HHS R01 DA047785NIH HHS R01AR78555NIH HHS R01DA047785NIH HHS R01 OD023700NIH HHS R01OD023700NIH HHS R21AR080761Pancreatic Cancer SPORE grantRally Foundation Outside the Box GrantSamuel Waxman Cancer Research FoundationShanghai Science and Technology Development Fund 23410710500the National Natural Science Foundation of China 81920108026the National Natural Science Foundation of China 82372594UCHAP pilot awardUllman Family Team Science AwardUniversity of Chicago Comprehensive Cancer Center (UCCCC) Duckworth Family Commercial Promise Award
6 · The paper itself

Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non-specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an effective approach for targeted drug delivery at the gastrointestinal (GI) tract. An ideal integration of synthetic material with intestinal epithelium entails an integrated and preferable chemically bonded interface between the hydrogel and mucosal surface. In this study, a photo-triggered coupling reaction is leveraged as the crosslinking platform to develop a mucosal-adhesive hydrogel, which is compatible with endoscope-directed drug delivery for UC treatment. The results demonstrated superior spatiotemporal specificity and drug pharmacokinetics with this delivery system in vivo. Delivery of different drugs with the hydrogel leads to greatly enhanced therapeutic efficacy and significantly reduced systemic drug exposure with rat colitis models. The study presents a strategy for targeted and persistent drug delivery for UC treatment.

Indexed as

Colitis, UlcerativeDrug Delivery SystemsHydrogelsIntestinal MucosaAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyHydrogelsendoscopic drug deliveryphotoreactive hydrogelulcerative colitis

Identifiers

PMID39900372
PMCPMC11948015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.