Evidence map›Paper›PMID 39900290›Full record

ArticleContemporary clinical trials2025

Effects of fermented and fiber-rich foods on maternal & offspring microbiome study (FeFiFo-MOMS) - Study design and methods.

Catherine P Ward, Dalia Perelman, Lindsay R Durand, Jennifer L Robinson, Kristen M Cunanan, Sailendharan Sudakaran, Roujheen Sabetan, Maggie J Madrigal-Moeller, Christopher Dant, Erica D Sonnenburg and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05123612 (Effects of Fermented & Fiber-rich Foods on Maternal & Offspring Microbiome Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05123612 naactive not recruitingnot on this map

Effects of Fermented & Fiber-rich Foods on Maternal & Offspring Microbiome Study

TypeinterventionalSponsorStanford UniversityRan2022 to 2029Enrolled135ConditionsPregnancy Related, Microbiome, Immune Function, InflammationArmsFiber, Fermented Foods
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Catherine P WardStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Dalia PerelmanStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Lindsay R DurandStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Jennifer L RobinsonStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Kristen M CunananQuantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Sailendharan SudakaranDepartment of Microbiology and Immunology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Roujheen SabetanStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Maggie J Madrigal-MoellerDepartment of Microbiology and Immunology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Christopher DantStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Erica D SonnenburgDepartment of Microbiology and Immunology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Justin L SonnenburgDepartment of Microbiology and Immunology, School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Christopher D GardnerStanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, CA 94305, USA. Electronic address: cgardner@stanford.edu.

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Impact of Diet on Intestinal Microbiota-Host DynamicsR01DK085025 · NIDDK · STANFORD UNIVERSITY · PI JUSTIN L SONNENBURG · 2010 to 2026
$6.4M
Cardiovascular and Chronic Disease Prevention Training ProgramT32HL161270 · NHLBI · STANFORD UNIVERSITY · PI CHRISTOPHER D GARDNER · 2022 to 2026
$2.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NHLBI NIH HHS T32 HL161270NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK085025NIH HHS S10 OD026929
6 · The paper itself

Abstract

backgroundRecent research underscores the crucial role of the gut microbiota in human health, particularly during states of altered homeostasis, including pregnancy. Additionally, it is not well understood how dietary changes during pregnancy affect the development of microbiomes of both mother and child.

methodsHere, we describe the study design and methods for our randomized controlled trial, the fermented and fiber-rich foods on maternal and offspring microbiome study (FeFiFo-MOMS). We enrolled 135 women during early pregnancy, randomizing them to one of four diet arms: increased fiber, increased fermented foods, increase in both, and no dietary intervention as a comparator arm. Samples were collected across pregnancy continuing to 18 months post-birth for clinical, microbiome, and immune marker analysis.

resultsOur trial design intended to investigate the effects of dietary interventions-specifically, increased intake of high-fiber and fermented foods-on maternal gut microbiota diversity and its subsequent transmission to infants.

conclusionThe FeFiFo-MOMS trial was designed to provide valuable insights into the modifiable dietary factors that could influence maternal and infant health through microbiota-mediated mechanisms and examine the broader implications of diet on pregnant mothers' and infants' health and disease. CLINICALTRIALS: govID:NCT05123612.

Indexed as

Dietary FiberFermented FoodsGastrointestinal MicrobiomeAdultDietFemaleHumansInfantInfant, NewbornPregnancyRandomized Controlled Trials as TopicDietary FiberFermented foodsHigh-fiber dietMicrobiomeNutritionPregnancyPrenatal

Identifiers

PMID39900290
PMCPMC12108452

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.