Evidence map›Paper›PMID 39900102›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Rapid Quantitative Assessment of Muscle Sodium Dynamics After Exercise Using

Mary A Neal, Carla F Bolano-Diaz, Mark Richardson, Jassi Michell-Sodhi, Robert Muni-Lofra, Meredith K James, Kieren G Hollingsworth, Heather Hilsden, Ian Wilson, Andrew M Blamire and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Comparative analysis ofMagma (New York, N.Y.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mary A NealTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-5634-7586
Carla F Bolano-DiazThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Mark RichardsonThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Jassi Michell-SodhiThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Robert Muni-LofraThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Meredith K JamesThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Kieren G HollingsworthTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Heather HilsdenThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Ian WilsonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Andrew M BlamireTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Volker StraubThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Peter E ThelwallTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Jordi Diaz-ManeraThe John Walton Muscular Dystrophy Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Funding

Jain Foundation
6 · The paper itself

Abstract

backgroundDysferlin plays a key role in cell membrane repair; its absence or malfunction in patients with dysferlin-deficient limb girdle muscular dystrophy leads to muscle fibre death. Muscle magnetic resonance (MR) imaging allows non-invasive and repeatable measurements that can report on pathological changes observed in dysferlinopathy patients (DP). We aimed to demonstrate the feasibility of utilising volume-localised

methodsAdult DP and age and sex matched healthy volunteers (HV) were recruited and scanned on a 3 T clinical MR scanner. Following baseline scans, participants performed physiotherapist-guided isometric dorsiflexion contractions until tibialis anterior (TA) muscle exhaustion. Dynamic volume-localised sodium-23 (

resultsTen DP (mean age ± standard deviation [SD]: 38.0 ± 10.8 years; 80% female) and 10 HV (mean age ± SD: 38.9 ± 11.5 years) were scanned. Baseline muscle water

conclusionsAssessment of TA muscle fat fraction,

Indexed as

ExerciseMagnetic Resonance ImagingMuscle, SkeletalMuscular Dystrophies, Limb-GirdleSodiumAdultCase-Control StudiesDysferlinFemaleHumansMaleMiddle AgedDysferlinSodiumbiomarkersdysferlinopathyimagingmuscle MRImuscular dystrophysodium MRI

Identifiers

PMID39900102
PMCPMC11790297

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.