Evidence map›Paper›PMID 39899936›Full record

ArticleBiochemical and biophysical research communications2025

Positive feedback loop between NRAS

Zhi-Zheng Li, Yu Cai, Tian-Tian Wang, Shuai Peng, Ji-Hong Zhao, Wei Tong, Jian-Gang Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhi-Zheng LiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Yu CaiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Tian-Tian WangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Shuai PengState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Ji-Hong ZhaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China.
Wei TongDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Jian-Gang RenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. Electronic address: rjg19870708@whu.edu.cn.

Funding

Novel Regulation of Oncogenic NRAS Signaling in Myeloid MalignanciesR01CA271523 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Wei Tong · 2022 to 2026
$2.7M
Regulation of FLT3 Signaling in LeukemiaR01CA282668 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Wei Tong · 2023 to 2026
$2.5M
NCI NIH HHS R01 CA271523NCI NIH HHS R01 CA282668
6 · The paper itself

Abstract

Recent findings implicate somatic NRAS

Indexed as

Alkyl and Aryl TransferasesEndothelial CellsFeedback, PhysiologicalMembrane ProteinsMutationrab GTP-Binding ProteinsCell MovementCell ProliferationGTP PhosphohydrolasesHumansHuman Umbilical Vein Endothelial CellsAlkyl and Aryl TransferasesGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanRab27B protein, humanrab GTP-Binding ProteinsEndotheliumERKNRASRAB27B

Identifiers

PMID39899936
PMCPMC11970572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.