ArticleACS macro letters2025
Versatile and Controlled Synthesis of Degradable, Water-Soluble Bottlebrush Polymers with Poly(disulfide) Backbones Derived from α-Lipoic Acid.
Article in ACS macro letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Mechanochemical Engineered Sulfur Copolymers Onto Group 13 and Related Fillers Through Lewis Acid-Base Pairing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hydrolytically Degradable Polyethylene Glycol Bottlebrush Polymers Address the Stability-Clearance Trade-Off for Drug Delivery.Polymer science & technology (Washington, D.C.) · 2026Article
- Article
- Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.Angewandte Chemie (International ed. in English) · 2026Article
- Recyclable Graft Polymer Enabled by RAFT Step-Growth Polymerization and Deconstruction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Direct Evidence for the Sulfonium-Mediated Photopolymerization of 1,2-Dithiolanes.Journal of the American Chemical Society · 2026Article
- Degradable Vinyl-Based Polymers by Radical Ring-Opening Polymerization: A User Guide.ACS polymers Au · 2026Article
- Dual-Pathway Strategy for Click-Type Functionalization and Programmable Polymer Deconstruction.Macromolecules · 2026Article
- Gene Delivery Mediated by Backbone-Degradable RAFT Copolymers.Biomacromolecules · 2026Article
- RAFT Step-Growth Polymerization via 'Grafting Through'.ACS polymers Au · 2025Article
- Oxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers.Angewandte Chemie (International ed. in English) · 2025Article
- Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers.Macromolecular rapid communications · 2025Article
- A Greener and More Scalable Synthesis of Biogenic Polydisulfides from Lipoic Acid.ChemSusChem · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bottlebrush (BB) polymers, with their densely grafted side chains and unique architecture, are highly advantageous for drug delivery due to their high functional group density for drug conjugation, unimolecular nature, and enhanced biodistribution properties. These attributes enable extended blood circulation half-life, improved tumor tissue penetration, and high tumoral drug accumulation. However, the typically nondegradable, all-carbon backbones of most BB polymers limit their suitability for applications requiring controlled clearance and biodegradability. To address this, we developed degradable BB polymers with poly(disulfide) backbones synthesized via reversible addition-fragmentation chain transfer (RAFT) copolymerization of α-lipoic acid (LA), a renewable and readily available compound, with acrylate-based inimers. These copolymers feature degradable backbones and initiating sites for subsequent BB synthesis. Using an atom transfer radical polymerization (ATRP)
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