ArticleJournal of medical entomology2025
Time-of-day changes in permethrin susceptibility and metabolic gene expression in Florida Aedes aegypti (Diptera: Culicidae).
Article in Journal of medical entomology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- High-resolution characterisation of diel activity rhythms inCurrent research in parasitology & vector-borne diseases · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Aedes aegypti (Linnaeus) is the principal mosquito vector for many of the most medically significant arboviruses that threaten global public health. A better understanding of time-of-day variation in insecticide resistance mediated by detoxifying enzymes in Ae. aegypti could allow for targeted insecticide applications when susceptibility is highest and the upregulation of detoxification enzymes is lowest. Using a susceptible and metabolically resistant field Ae. aegypti strain from Florida, we investigated simulated photoperiodic changes in permethrin susceptibility and upregulation of detoxification enzymes by measuring permethrin LD50 and expression of detoxification genes (GSTE7, GSTE2, CCEae3A, CYP9J28, and CYPBB2) for both strains every 4 h over a 24 h (12:12 h light: dark) cycle. We found that in both Ae. aegypti strains, permethrin susceptibility was lower during the day as compared to evening, with susceptibility lowest at dusk (18:00) and highest between 02:00 and 14:00. Although no significant changes in gene expression over time were observed in the susceptible Ae. aegypti strain, we documented increased expression of all investigated detoxification genes in the metabolically resistant field Ae. aegypti strain during the night (18:00 to 02:00) as compared to the day (06:00 to 14:00). These data suggest that permethrin applications made between midnight and dawn (06:00) may be more effective against Ae. aegypti as compared to applications made at dusk (approximately 18:00).
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Registered trials
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