Evidence map›Paper›PMID 39899716›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A 5,000-fold increase in the HAT reactivity of a nonheme Fe

Nabhendu Pal, Jin Xiong, Mehmet Jahja, Sami Mahri, Victor G Young, Yisong Guo, Marcel Swart, Lawrence Que

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. A 5,000-fold increase in the HAT reactivity of a nonheme FeProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nabhendu PalDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-5559-1122
Jin XiongDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0001-7443-0554
Mehmet JahjaInstitut de Química Computacional i Catàlisi, University of Girona, Girona 17003, Spain.
Sami MahriInstitut de Química Computacional i Catàlisi, University of Girona, Girona 17003, Spain.
Victor G YoungDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455.
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213.ORCID 0000-0002-4132-3565
Marcel SwartInstitut de Química Computacional i Catàlisi, University of Girona, Girona 17003, Spain.ORCID 0000-0002-8174-8488
Lawrence QueDepartment of Chemistry, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-0989-2813

Funding

Elucidate Mechanisms of Quinolone Alkaloid Biosynthesis via Iron(II)/2-Oxoglutarate Dependent Enzymes: Diverse, but Controlled ReactivityR01GM125924 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI Yisong Guo · 2018 to 2026
$3.3M
O-O Bond Activation (and Formation) at Bimetallic Enzyme Active SitesR35GM131721 · NIGMS · UNIVERSITY OF MINNESOTA · PI QUE, LAWRENCE · 2019 to 2023
$1.7M
AEI/MCIN PID2020-114548 GB-I00 to MSFoundation for the NIH (FNIH) R01 GM-125924 to YGFoundation for the NIH (FNIH) R35 GM-131721 to LQNIGMS NIH HHS R01 GM125924NIGMS NIH HHS R35 GM131721
6 · The paper itself

Abstract

A pentadentate [N5] ligand (N2Py2Pz) based on the classic N4Py (

Indexed as

C-H bond cleavageelectrophilicityhigh-valent Fe=Ooxoiron(IV)pyrazole

Identifiers

PMID39899716
PMCPMC11831173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.