Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Maxum E Paul *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520.ORCID 0000-0001-5551-1893
Di Chen *Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Kimberly J VishDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520.
Nathaniel L LarteyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0002-9810-2720
Elizabeth HughesTransgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI 48109.
Zachary T FreemanTransgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI 48109.
Thomas L SaundersTransgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI 48109.ORCID 0000-0003-2015-101X
Amy L StieglerDepartment of Pharmacology, Yale University, New Haven, CT 06520.
Philip D KingDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Titus J BoggonDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520.
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2M
Ras-MAPK Regulation of Lymphatic Vessel Valve DevelopmentR01HL120888 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHILIP D KING · 2015 to 2026
$4.6M
Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal MalformationR01NS117609 · NINDS · YALE UNIVERSITY · PI Titus Jonathon Boggon, Kristopher T. Kahle · 2020 to 2026
$3.3M
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4M
Molecular pathogenetic mechanisms in CM-AVMR01HL146352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KING, PHILIP D · 2020 to 2023
$2.2M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Inter-Domain Regulation of p120RasGAPF31HL167578 · NHLBI · YALE UNIVERSITY · PI PAUL, MAXUM · 2023 to 2025
$146k
Structural Investigation of p120RasGAP's regulation by phosphorylated binding partnersF31HL165968 · NHLBI · YALE UNIVERSITY · PI VISH, KIMBERLY JEAN · 2022 to 2024
$143k
HHS | NIH | National Cancer Institute (NCI) P30CA046592HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL165968HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL167578HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL120888HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146352HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM007324HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008283HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS117609NCI NIH HHS P30 CA046592NHLBI NIH HHS F31 HL165968NHLBI NIH HHS F31 HL167578NHLBI NIH HHS R01 HL120888NHLBI NIH HHS R01 HL146352NIGMS NIH HHS P30 GM124165NIGMS NIH HHS T32 GM007324NIGMS NIH HHS T32 GM008283NIH HHS S10 OD021527NINDS NIH HHS R01 NS109358NINDS NIH HHS R01 NS117609
6 · The paper itself
Abstract
Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP domain, and in RasGAP (p120GAP, p120RasGAP;
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.