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ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization.

Simone Schwarz, Louise Denis, Emmanuel Nedoschill, Adrian Buehler, Vera Danko, Alina C Hilger, Francisco Brevis Nuñez, Nikola R Dürr, Martin Schlunz-Hendann, Friedhelm Brassel and 10 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Microvascular Ultrasound Imaging in the Neonatal Brain: From Advanced Doppler to Super-Resolution.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025
    Review
  8. Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Simone SchwarzDepartment of Neonatology and Pediatric Intensive Care Medicine, Sana Clinics Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany.
Louise DenisLaboratoire d'Imagerie Biomédicale, Sorbonne Université, CNRS, INSERM, 15 Rue de l'Ecole de Médecine, 75006, Paris, France.
Emmanuel NedoschillDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Adrian BuehlerDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Vera DankoDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Alina C HilgerDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Francisco Brevis NuñezDepartment of Neonatology and Pediatric Intensive Care Medicine, Sana Clinics Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany.
Nikola R DürrClinic for Radiology and Neuroradiology, Sana Clinics Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany.
Martin Schlunz-HendannClinic for Radiology and Neuroradiology, Sana Clinics Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany.
Friedhelm BrasselClinic for Radiology and Neuroradiology, Sana Clinics Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany.
Ursula Felderhoff-MüserDepartment of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Heiko ReutterDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Joachim WoelfleDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Jörg JüngertDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Christian Dohna-SchwakeDepartment of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Nora BrunsDepartment of Pediatrics I, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Adrian P RegensburgerDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Olivier CoutureLaboratoire d'Imagerie Biomédicale, Sorbonne Université, CNRS, INSERM, 15 Rue de l'Ecole de Médecine, 75006, Paris, France.
Henriette MandelbaumDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.
Ferdinand KnielingDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Loschgestraße 15, 91054, Erlangen, Germany.ORCID https://orcid.org/0000-0002-3535-2626

Funding

Deutsche Gesellschaft für Ultraschall in der MedizinHORIZON EUROPE European Research Council 772786HORIZON EUROPE European Research Council ERC Starting Grant No 101115742
6 · The paper itself

Abstract

During the first days of neonatal growth, the central nervous system (CNS) develops self-regulatory mechanisms to ensure constant cerebral perfusion. However, this vascular neogenesis takes place at a microscopic scale that cannot be observed with current clinical imaging techniques. Ultrasound localization microscopy (ULM) allows us to observe micro-vessels of the order of a few microns at depths of several centimeters. This can be done using conventional clinical ultrasound scanners and contrast sequences (CEUS). In this study, ULM is used to observe the human microvasculature in neonatal patients undergoing treatment for life-threatening malformations forming direct connections between the cerebral arterial and venous systems. It is observed that neuroendovascular treatment of neonatal arteriovenous malformations causes remodeling and reorganization of the cerebral vasculature by also activating corticomedullary vascular connections. ULM enables us to follow microvascular changes in human neonates with high spatio-temporal resolution. ULM may provide a novel clinical translatable tool, particularly including cerebral imaging in very young patients.

Indexed as

BrainCerebrovascular CirculationIntracranial Arteriovenous MalformationsFemaleHumansInfant, NewbornMaleMicrovesselsUltrasonographyCEUSmicrobubblessuper‐resolution imagingultrasoundultrasound localization microscopyVein of Galen malformation

Identifiers

PMID39899647
PMCPMC11948062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.