SynthesisPLoS neglected tropical diseases2025
Clinical manifestations associated with the chronic phase of Chikungunya Fever: A systematic review of prevalence.
Synthesis in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Characterization of the clinical forms of chronic chikungunya: an observational cohort study in Rio de Janeiro.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026Observational
- Cluster of imported chikungunya virus infections in travelers returning from Seychelles to Berlin, December 2025-April 2026.New microbes and new infections · 2026Article
- From symptom management to immune prevention: a comprehensive review of chikungunya treatment and vaccine development.Folia microbiologica · 2026Review
- Dual-Model framework for CHIKV transmission modeling: ODE and Petri Net Analysis of the 2025 Foshan outbreak.BMC public health · 2026Article
- Unveiling Clinical Phenotypes in Chronic Chikungunya Disease: Insights from a Brazilian Observational Study.Tropical medicine and infectious disease · 2026Article
- Chronic phase of Chikungunya: understanding the impact of joint pain using data science and artificial intelligence.Tropical medicine and health · 2026Article
- Clinical Features and Factors Associated with Disease Severity in Acute Chikungunya Fever: A Retrospective Analysis.Infection and drug resistance · 2026Article
- Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1.PloS one · 2026Article
- Epidemiology of Chikungunya Hospitalizations, Brazil, 2014-2024.Emerging infectious diseases · 2025Article
- Zika virus infection disturbs development of human muscle progenitor cells.Frontiers in cellular and infection microbiology · 2025Article
- Chikungunya fever: pathogenesis and mechanisms underlying pain symptoms.Frontiers in immunology · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this systematic review of prevalence is to observe and discuss the clinical manifestations of Chikungunya Virus disease in its chronic phase.
methodsTo be eligible, the observational studies should accompany the individuals for at least six months. The research was conducted using electronic databases MEDLINE and EMBASE. The methodological quality was evaluated using the "Joanna Briggs Institute's critical appraisal checklist for studies reporting prevalence data" tool.
resultsThe search has found 175 articles. The application of the inclusion criteria defined a total of 29 selected studies. From the included studies, only one did not present arthralgia as a prevalent symptom in the chronic phase. Other signs and symptoms observed were: fatigue; sleep disorders; myalgia; skin lesions; depression; digestive disorders.
conclusionBecause it is an often incapacitating symptom, arthralgia can affect the individuals' quality of life, with implications in their social and work life. Since the chronic phase is common in infected individuals, all levels of health care should be prepared to monitor, in the medium to long term, the patients affected by this condition.
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