Evidence map›Paper›PMID 39899539›Full record

ArticlePloS one2025

4-Hydroxy-2-nonenal causes nuclear accumulation of p62 by inhibiting Xpo1 and promoting the proteolytic pathway in the nucleus.

Emi Kayama, Ning Baoshuo, Rinna Tatsuno, Kanako Nishi, Elsayed S I Mohammed, Yumi Abiko, Toru Yanagawa, Satoru Takahashi, Eiji Warabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emi KayamaDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Ning BaoshuoDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Rinna TatsunoDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Kanako NishiDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Elsayed S I MohammedDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yumi AbikoGraduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Toru YanagawaDepartment of Clinical Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID https://orcid.org/0000-0003-0868-2563
Satoru TakahashiDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Eiji WarabiDepartment of Biomedical Science, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

p62, an adapter protein involved in selective autophagy, is mainly found in the cytoplasm under normal conditions. Because p62 has nuclear localization signal (NLS) and a nuclear export signal, it has been suggested that p62 shuttles between the nucleus and cytoplasm. We studied the effect of 4-hydroxy-nonenal (4-HNE), an endogenous lipid peroxidation product, on intracellular p62 distribution in mouse embryonic fibroblasts. We found that treatment of 4-HNE causes p62 translocation from the cytoplasm to the nucleus. Further analysis revealed that 4-HNE directly binds to exportin-1 (Xpo1), essential protein for nuclear export of various proteins. Further analysis 4-HNE enhanced intranuclear EGFP-NLS-CL1 degradation in a p62-dependent manner. Our results suggest that 4-HNE changes p62 localization to the nucleus by inhibiting Xpo1 and might affect intranuclear protein quality control.

Indexed as

AldehydesCell NucleusKaryopherinsProteolysisReceptors, Cytoplasmic and NuclearActive Transport, Cell NucleusAnimalsExportin 1 ProteinFibroblastsHumansMiceProtein TransportSequestosome-1 Protein4-hydroxy-2-nonenalAldehydesExportin 1 ProteinKaryopherinsReceptors, Cytoplasmic and NuclearSequestosome-1 ProteinSqstm1 protein, mouse

Identifiers

PMID39899539
PMCPMC11790078

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.