Evidence map›Paper›PMID 39899356›Full record

ArticleEnvironmental health perspectives2025

IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards.

David M DeMarini, William Gwinn, Emily Watkins, Brad Reisfeld, Weihsueh A Chiu, Lauren Zeise, Dinesh Barupal, Parveen Bhatti, Kevin Cross, Eugenia Dogliotti and 30 more

Abstract read
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Air Pollutants in Puerto Rico: Key Pollutants and Carcinogenic Properties.International journal of environmental research and public health · 2025
    Review
  5. Article
  6. Mapping assays to the key characteristics of carcinogens to support decision-making.Database : the journal of biological databases and curation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

David M DeMariniUS Environmental Protection Agency (EPA; Retired), Research Triangle Park, North Carolina, USA.
William GwinnDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Emily WatkinsDepartment of Life Sciences, University of Roehampton, London, UK.
Brad ReisfeldDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado, USA.
Weihsueh A ChiuSchool of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Lauren ZeiseOffice of Environmental Health Hazard Assessment, California EPA, Sacramento, California, USA.
Dinesh BarupalDepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, USA.
Parveen BhattiBC Cancer Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Kevin CrossInstem, Columbus, Ohio, USA.
Eugenia DogliottiDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, Italy.
Jason M FritzUS EPA, Denver, Colorado, USA.
Dori GermolecDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Maria Helena Guerra AndersenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Kathryn Z GuytonBoard on Environmental Studies and Toxicology, National Academies of Sciences, Engineering, and Medicine, Washington, District of Columbia, USA.
Jennifer JinotUS EPA (Retired), Washington, District of Columbia, USA.
David H PhillipsDepartment of Analytical, Environmental & Forensic Sciences, King's College London, London, UK.
Roger R ReddelFaculty of Medicine and Health, University of Sydney, Sydney, Australia.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA.
Martin van den BergDepartment of Population Health, Utrecht University, Utrecht, the Netherlands.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Paolo VineisSchool of Public Health, Imperial College, London, UK.
Amy WangDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.ORCID 0000-0002-6121-3937
Maurice WhelanEuropean Commission, Joint Research Centre, Ispra, Italy.
Akram GhantousEpigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Michael KorenjakEpigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Jiri ZavadilEpigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Zdenko HercegEpigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC), Lyon, France.
Sandra PerdomoGenomic Epidemiology Branch, IARC, Lyon, France.
Laure DossusNutrition and Metabolism Branch, IARC, Lyon, France.
Shirisha ChittiboyinaIARC Monographs Programme, IARC, Lyon, France.
Danila CuomoIARC Monographs Programme, IARC, Lyon, France.
John KaldorIARC Monographs Programme, IARC, Lyon, France.
Elisa PasqualIARC Monographs Programme, IARC, Lyon, France.
Gabrielle RiguttoIARC Monographs Programme, IARC, Lyon, France.
Roland WedekindIARC Monographs Programme, IARC, Lyon, France.
Caterina FacchinIARC Monographs Programme, IARC, Lyon, France.
Fatiha El GhissassiIARC Monographs Programme, IARC, Lyon, France.
Aline de ContiIARC Monographs Programme, IARC, Lyon, France.
Mary K Schubauer-BeriganIARC Monographs Programme, IARC, Lyon, France.ORCID 0000-0002-5175-924X
Federica MadiaIARC Monographs Programme, IARC, Lyon, France.ORCID 0000-0002-8438-0957

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Sakhila Banu · 2019 to 2026
$13.0M
IARC Monographs on the Identification of Carcinogenic Hazards to HumansR01CA033193 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCHUBAUER-BERIGAN, MARY K. · 2021 to 2025
$4.9M
NCATS NIH HHS UL1 TR004419NCI NIH HHS R01 CA033193NIEHS NIH HHS P30 ES029067World Health Organization 001
6 · The paper itself

Abstract

backgroundThe 10 key characteristics (KCs) of carcinogens form the basis of a framework to identify, organize, and evaluate mechanistic evidence relevant to carcinogenic hazard identification. The 10 KCs are related to mechanisms by which carcinogens cause cancer. The

objectivesWe sought to report the main outcomes of an IARC Scientific Workshop convened by the IARC to establish appropriate, transparent, and uniform application of the KCs in future

methodsA group of experts from different disciplines reviewed the DISCUSSION: Consensus was reached on how to enhance the use of

Indexed as

CarcinogensEnvironmental ExposureNeoplasmsAnimalsCarcinogenicity TestsHumansInternational AgenciesRisk AssessmentCarcinogens

Identifiers

PMID39899356
PMCPMC11790013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.