Evidence map›Paper›PMID 39899236›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Development and Efficacy Evaluation of Multivalent DNA Vaccine against Brucellosis.

Y M Khodarovich, Maha A Elshazly, W S Shell, S A Nassif, D A Devrishov, S A Magomedova, S N Marzanova, S M Deyev

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Y M KhodarovichShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. khodarovich@mail.ru.
Maha A ElshazlyCentral Laboratory for Evaluation of Veterinary Biologics (CLEVB)-Agriculture Research Center (ARC), Cairo, Egypt.
W S ShellCentral Laboratory for Evaluation of Veterinary Biologics (CLEVB)-Agriculture Research Center (ARC), Cairo, Egypt.
S A NassifCentral Laboratory for Evaluation of Veterinary Biologics (CLEVB)-Agriculture Research Center (ARC), Cairo, Egypt.
D A DevrishovSkryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia.
S A MagomedovaSkryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia.
S N MarzanovaSkryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia.
S M DeyevShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attenuated live Brucella strains are currently used in vaccines against brucellosis, causing serious side effects in animals and being hardly suitable for human vaccination. To develop a safer vaccine against brucellosis, plasmid DNA was constructed to express six Brucella proteins in mammalian cells. Linear polyethylenimine was used to increase the efficiency of DNA delivery into cells. Data on optimization of the conditions for the formation of DNA-polyethylenimine complexes were described. A single intramuscular or subcutaneous injection of plasmid DNA complexes with polyethylenimine at a low dose (20 μg/mouse) was shown to exert a reliable protective effect against subsequent challenge with a test Brucella strain.

Indexed as

BrucellaBrucella VaccineBrucellosisVaccines, DNAAnimalsFemaleHumansMiceMice, Inbred BALB CPlasmidsPolyethyleneimineBrucella VaccinePolyethyleneimineVaccines, DNAbrucellosisDNA vaccinein vivo transfectionpolycistronic RNApolyethylenimine

Identifiers

PMID39899236

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.