Evidence map›Paper›PMID 39899190›Full record

ArticleGeroScience2025

Intrinsic brain functional connectivity mediates the relationship between psychological resilience and cognitive decline in ageing.

Menglu Chen, Mengxia Gao, Junji Ma, Tatia M C Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Menglu ChenState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China.
Mengxia GaoState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China.
Junji MaState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China.
Tatia M C LeeState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR, China. tmclee@hku.hk.

Funding

Hong Kong Branch of Southern Laboratory of Ocean Science and Engineering Guangdong Laboratory 2023B1212120004the Hong Kong Research Grant Council Collaborative Research Fund C7069-19G
6 · The paper itself

Abstract

Ageing individuals often experience cognitive decline and intrinsic functional connectivity (FC) changes. Psychological resilience, a personality trait that reflects the capacity to adapt and cope with age-related challenges, plays a key role in mitigating cognitive decline. In this study involving 101 older adults, we investigated how psychological resilience influences cognitive decline measured by processing speed. Particularly, we obtained resting-state functional magnetic resonance imaging (fMRI) to assess how intrinsic FC, represented by degree centrality, modulates the relationship between resilience and processing speed. Our results indicated while psychological resilience positively predicted processing speed, this relationship was mainly driven by education. Additionally, the degree centrality of both thalamus and caudate negatively correlated with processing speed and resilience. Notably, the degree centrality of both thalamus and caudate significantly mediated the relationship between resilience and processing speed. These findings suggest that psychological resilience could protect against age-related cognitive decline via its influence on FC in the thalamus and caudate, highlighting these areas as potential intervention targets for reducing cognitive decline in ageing people.

Indexed as

AgingBrainCognitive DysfunctionResilience, PsychologicalAgedAged, 80 and overCaudate NucleusFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedThalamusAgeingFunctional connectivityProcessing speedPsychological resilienceResting-state fMRI

Identifiers

PMID39899190
PMCPMC12397464

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.