Evidence map›Paper›PMID 39899148›Full record

ReviewMolecular biology reports2025

Intrinsic and extrinsic modulators of human dental pulp stem cells: advancing strategies for tissue engineering applications.

Fatemeh Kavakebian, Alireza Rezapour, Reihaneh Seyedebrahimi, Mohsen Eslami Farsani, Massoumeh Jabbari Fakhr, Saeedeh Zare Jalise, Shima Ababzadeh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh KavakebianTissue Engineering and Applied Cell Sciences Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.ORCID http://orcid.org/0000-0001-6510-9814
Alireza RezapourTissue Engineering and Applied Cell Sciences Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Reihaneh SeyedebrahimiAnatomy Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Mohsen Eslami FarsaniAnatomy Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Massoumeh Jabbari FakhrTissue Engineering and Applied Cell Sciences Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Saeedeh Zare JaliseTissue Engineering and Applied Cell Sciences Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Shima AbabzadehTissue Engineering and Applied Cell Sciences Department, School of Medicine, Qom University of Medical Sciences, Qom, Iran. shababzadeh@muq.ac.ir.ORCID http://orcid.org/0000-0002-3481-9714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review focuses on dental pulp stem cells (DPSCs) which are mesenchymal stem cells (MSCs) and originating from the neural crest. These cells possess a high capacity for self-renewal and multilineage differentiation. Because of these traits, they represent promising sources for tissue engineering, regenerative medicine, and clinical applications. The objective of this study was to assess the extrinsic and intrinsic factors influencing DPSC characteristics and their potential in tissue engineering. This review discusses the external and internal factors affecting DPSC properties, including proliferation, migration, differentiation, and gene expression post extraction. Additionally, it explores the impact of the microenvironment-its composition and physical properties-and genetic and epigenetic regulation on DPSC behavior. Variations in the microenvironment and genetic regulation play pivotal roles in modulating DPSC functions, including their proliferation and differentiation potential. Intrinsic and extrinsic factors are key barriers to realizing the full therapeutic potential of DPSCs. A deeper understanding of the extrinsic and intrinsic factors affecting DPSC behavior is critical for optimizing their use in regenerative medicine, particularly for dental and craniofacial applications. Although DPSCs hold significant promise, challenges remain, and this review provides insights into the current limitations and future directions for DPSC-based therapies. Researchers and clinicians are offered a comprehensive resource for advancing the field.

Indexed as

Dental PulpMesenchymal Stem CellsStem CellsTissue EngineeringCell DifferentiationCell MovementCell ProliferationHumansRegenerative MedicineDental pulp stem cellsDifferentiationIntrinsic and extrinsic factorsMultipotencyProliferationTissue engineering

Identifiers

PMID39899148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.