Evidence map›Paper›PMID 39899038›Full record

ArticlePsychopharmacology2025

Reduced GIRK expression in midbrain dopamine neurons during prolonged abstinence from fentanyl self-administration.

Narges Pachenari, Amy L Channell, Andrew J Belilos, Samuel J Dienel, Khaled Moussawi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Narges PachenariDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. n.pachenari@gmail.com.
Amy L ChannellDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew J BelilosIntramural Research Program, National Institute On Drug Abuse, Baltimore, MD, USA.
Samuel J DienelDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Khaled MoussawiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. khaled.moussawi@ucsf.edu.ORCID http://orcid.org/0000-0001-6378-0428

Funding

TMS effects on circuit plasticity and drug seeking in mice - Diversity SupplementR00DA048085 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOUSSAWI, KHALED · 2021 to 2023
$930k
Intramural Research Program, National Institute on Drug Abuse DA048085NIDA NIH HHS K99 DA048085NIDA NIH HHS R00 DA048085
6 · The paper itself

Abstract

rationaleDespite decades of research and medical development, relapse to drug seeking continues to be a significant challenge in the treatment of substance use disorders. GABA

objectivesIn this study we aimed to answer the following questions: first, can we use GABA APPROACH: To this end, we tested the effects of a novel GABA

resultsOur results show that KK-92A inhibits relapse to fentanyl but not sucrose-seeking in rats, and fentanyl SA results in reduced mRNA levels of the G protein-coupled inwardly rectifying potassium channel subtypes 2 and 3 (GIRK

conclusionThese findings suggest that PAMs like KK-92A are a potential therapeutic strategy for opioid use disorder and their effect is likely due to rectifying GABA

Indexed as

Dopaminergic NeuronsFentanylG Protein-Coupled Inwardly-Rectifying Potassium ChannelsMesencephalonAnalgesics, OpioidAnimalsDrug-Seeking BehaviorGABA-B Receptor AgonistsMaleOpioid-Related DisordersRatsRats, Sprague-DawleyReceptors, GABA-BSelf AdministrationAnalgesics, OpioidFentanylGABA-B Receptor AgonistsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsReceptors, GABA-BDopamineFentanylGABAB receptorsGIRK channelsPositive allosteric modulatorVentral tegmental area

Identifiers

PMID39899038
PMCPMC12226691

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.