Evidence map›Paper›PMID 39898998›Full record

ArticleACS applied materials & interfaces2025

Influence of Pluronic F68 on Size Stability and Acoustic Behavior of Monodisperse Phospholipid-Coated Microbubbles Produced at Room Temperature.

Yuchen Wang, Sander Spiekhout, Ana Walgode, Gonzalo Collado-Lara, Antonius F W van der Steen, Nico de Jong, Johannes G Bosch, Benjamin R G Johnson, Klazina Kooiman

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In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuchen WangBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.ORCID 0000-0002-3251-0529
Sander SpiekhoutBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Ana WalgodeBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Gonzalo Collado-LaraBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Antonius F W van der SteenBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Nico de JongBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Johannes G BoschBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.
Benjamin R G JohnsonMolecular and Nanoscale Physics Group, School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT, United Kingdom.
Klazina KooimanBiomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus MC, Rotterdam 3015 GD, The Netherlands.ORCID 0000-0002-0607-4989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound contrast agents, comprised of phospholipid-coated microbubbles, can be produced as monodisperse populations using a microfluidic flow-focusing device. However, microbubble coalescence remains a significant challenge. High production temperatures (e.g., 55 °C) can be used to suppress coalescence, but it complicates the microfluidic device design and is incompatible with targeting agents and drug conjugates. This study investigates the production of monodisperse microbubbles at room temperature with the addition of the amphiphilic surfactant Pluronic F68. Two 1,2-distearoyl-

Indexed as

Contrast MediaMicrobubblesPhospholipidsPoloxamerAcousticsParticle SizePolyethylene GlycolsTemperatureContrast MediaPhospholipidsPoloxamerPolyethylene Glycolsmonodisperse microbubblesphospholipid coatingPluronic F68resonance behaviorshell elasticitystabilitysubharmonicultrasound contrast agents

Identifiers

PMID39898998
PMCPMC11826509

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.