Evidence map›Paper›PMID 39898808›Full record

ArticleeLife2025

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice.

Christian Thome, Jan Maximilian Janssen, Seda Karabulut, Claudio Acuna, Elisa D'Este, Stella J Soyka, Konrad Baum, Michael Bock, Nadja Lehmann, Johannes Roos and 11 more

Erratum issuedAbstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Christian ThomeInstitute of Anatomy and Cell Biology, Johannes Kepler University, Linz, Austria.ORCID https://orcid.org/0000-0002-3344-8683
Jan Maximilian JanssenInstitute of Anatomy and Cell Biology, Johannes Kepler University, Linz, Austria.
Seda KarabulutInstitute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Claudio AcunaChica and Heinz Schaller Research Group, Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
Elisa D'EsteOptical Microscopy Facility, Max Planck Institute for Medical Research, Heidelberg, Germany.
Stella J SoykaInstitute of Anatomy and Cell Biology, Dept. of Functional Neuroanatomy, Heidelberg University, Heidelberg, Germany.
Konrad BaumInstitute of Anatomy and Cell Biology, Johannes Kepler University, Linz, Austria.
Michael BockInstitute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nadja LehmannInstitute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0003-4801-3057
Johannes RoosInstitute of Anatomy and Cell Biology, Johannes Kepler University, Linz, Austria.
Nikolas A StevensInstitute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-5592-3326
Masashi HasegawaGerman Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, Bonn, Germany.
Dan A GaneaDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Chloé M BenoitGerman Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, Bonn, Germany.
Jan GründemannGerman Center for Neurodegenerative Disease (DZNE), Neural Circuit Computations, Bonn, Germany.
Lia Y MinDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-3977-1684
Kalynn M BirdDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.
Christian SchultzInstitute of Neuroanatomy, Mannheim Center for Translational Neuroscience (MCTN), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vann BennettDepartment of Biochemistry, Duke University Medical Center, Durham, United States.
Paul M JenkinsDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-4207-5823
Maren EngelhardtInstitute of Anatomy and Cell Biology, Johannes Kepler University, Linz, Austria.ORCID https://orcid.org/0000-0001-8020-6604

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
Convergent mechanisms for neurodevelopmental disorder genesR01MH126960 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nadav Ahituv, Kevin J Bender · 2021 to 2026
$3.5M
Deutsche Forschungsgemeinschaft EN 1240/2-1Deutsche Forschungsgemeinschaft PN 458054460Deutsche Forschungsgemeinschaft SFB 1134,TP03European Research Council Starting Grant 803870Interdepartmental Training in Pharmacological Sciences T32GM140223NIGMS NIH HHS T32 GM140223NIH HHS R01MH126960NIMH NIH HHS R01 MH126960Swiss National Science Foundation PP00P3_170672
6 · The paper itself

Abstract

The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post-hoc approaches since no robust murine in vivo live reporters exist. Here, we introduce a reporter line in which the AIS is intrinsically labeled by an ankyrin-G-GFP fusion protein activated by Cre recombinase, tagging the native

Indexed as

AnkyrinsAxon Initial SegmentAxonsAction PotentialsAnimalsGenes, ReporterGreen Fluorescent ProteinsMiceMice, TransgenicMicroscopy, ConfocalPatch-Clamp TechniquesRecombinant Fusion ProteinsAnk3 protein, mouseAnkyrinsGreen Fluorescent ProteinsRecombinant Fusion ProteinsAIS plasticityankryin-Gaxon initial segmentlive imagingmouseneurosciencenode of Ranvier

Identifiers

PMID39898808
PMCPMC11790247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.