ArticleJACC. Advances2025
Association of Longitudinal Change in Ambulatory Blood Pressure With Cognitive Decline in Older Adults.
Article in JACC. Advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Blood pressure variability and frailty: mechanisms, evidence, and clinical implications.International urology and nephrology · 2026Review
- Recent topics in hypertensive dementia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There has been no study about the association of longitudinal change in ambulatory blood pressure (BP) variability and level with cognitive decline. Objectives: The purpose of the study was to evaluate whether BP changes via ambulatory BP monitoring predict cognitive decline progression. Methods: Twice-annual ambulatory BP readings were examined during 5 years and their relationship with changes in the Japanese version of the Montreal Cognitive Assessment (MoCA-J) scores. BP variability was assessed using SD, coefficient of variation, and average real variability (ARV). Cognitive decline, defined as a change in the MoCA-J score, was assessed, with the threshold set at the quartile showing the greatest decrease, which we categorized as cognitive dysfunction (-4 points or less). Results: Among 206 participants (mean age 79.9 [± 7.5] years), baseline 24-hour systolic blood pressure (SBP)/diastolic blood pressure (DBP) averaged 115.2/67.0 mm Hg. Over 4.98 years (IQR: 4.94-5.04 years), MoCA-J scores showed a nonsignificant decline from 20.2 (± 0.4) to 19.9 (± 0.4). A generalized linear mixed model showed that increased SD of daytime SBP (-0.064 [95% CI: -0.121 to -0.007]; Conclusions: In older adults with controlled BP, increased BP variability was linked to cognitive decline, warranting further study as a prevention target.
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Registered trials
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