ArticleCureus2024
Statistical Analysis of Multiple Vaccine Effectiveness Against COVID-19 Variants: Integrating Immune Response Dynamics.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aims to evaluate the association between multiple COVID-19 vaccine doses and daily confirmed cases, incorporating immune response delays to better understand vaccination efficacy. We investigated the effectiveness of multiple COVID-19 vaccinations, with particular emphasis on viral variants, by integrating immune response dynamics into the statistical analysis to provide a more accurate assessment of vaccination outcomes. Detailed data on vaccination numbers and confirmed COVID-19 cases were obtained from the official Korean Ministry of the Interior and Safety website. Multiple linear regression was applied to evaluate the effectiveness of each vaccine dose against different COVID-19 variants. This approach offered a clearer understanding of how vaccination influenced the spread of COVID-19 over time. By accounting for delay periods associated with immune responses, we aimed to provide more accurate insights into the effectiveness of each vaccine dose. The results underscored the impact of multiple vaccinations when incorporating immune response timing and revealed notable differences in the responses of the Delta and Omicron variants to multiple doses. While significant effectiveness was observed against the Omicron variant, a similar positive effect was not evident for the Delta variant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.