Evidence map›Paper›PMID 39898043›Full record

ArticleiScience2025

Molecular simulations reveal intricate coupling between agonist-bound β-adrenergic receptors and G protein.

Yanxiao Han, John R D Dawson, Kevin R DeMarco, Kyle C Rouen, Khoa Ngo, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E Clancy, Yang K Xiang, Surl-Hee Ahn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanxiao HanDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
John R D DawsonDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Kevin R DeMarcoDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Kyle C RouenDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Khoa NgoDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Slava BekkerAmerican River College, Sacramento, CA 95841, USA.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Colleen E ClancyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
Yang K XiangDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Surl-Hee AhnDepartment of Chemical Engineering, University of California, Davis, Davis, CA 95616, USA.
Igor VorobyovDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Digital Twins from the Atom to the RhythmR01HL174001 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLEEN E CLANCY, Luis F Santana · 2024 to 2026
$2.4M
UC Davis Training Program in Chemical BiologyT32GM136597 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHEILA Sue DAVID, Marie C. Heffern · 2021 to 2026
$1.7M
Investigation of state-specific drug binding to cardiac ion channels to reveals mechanisms of arrhythmogenesisF31HL174025 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROUEN, KYLE C · 2024 to 2025
$84k
NHLBI NIH HHS F31 HL174025NHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL174001NHLBI NIH HHS T32 HL086350NIGMS NIH HHS T32 GM136597
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) and G proteins transmit signals from hormones and neurotransmitters across cell membranes, initiating downstream signaling and modulating cellular behavior. Using advanced computer modeling and simulation, we identified atomistic-level structural, dynamic, and energetic mechanisms of norepinephrine (NE) and stimulatory G protein (G

Indexed as

Computational bioinformaticsProtein structure aspects

Identifiers

PMID39898043
PMCPMC11787599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.