Evidence map›Paper›PMID 39897960›Full record

ArticleFrontiers in endocrinology2024

Diminished ovarian reserve is associated to euploidy rate: a single center study.

Edoardo Carnesi, Stefano Castellano, Elena Albani, Andrea Busnelli, Antonella Smeraldi, Ozgur Bulbul, Emanuela Morenghi, Valentina Immediata, Paolo Emanuele Levi-Setti

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Edoardo CarnesiDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Stefano CastellanoDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Elena AlbaniDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Andrea BusnelliDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Antonella SmeraldiDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Ozgur BulbulDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Emanuela MorenghiDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Valentina ImmediataDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.
Paolo Emanuele Levi-SettiDivision of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Reproductive success shows a well-documented decline with advancing maternal age, primarily due to chromosomal abnormalities (aneuploidies) in embryos. While ovarian reserve markers such as Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) traditionally serve as quantitative predictors of fertility, emerging evidence suggests they may also reflect oocyte quality, particularly in patients with Diminished Ovarian Reserve (DOR). The relationship between these biomarkers and embryo chromosomal status remains complex and poorly understood. Methods: We conducted a retrospective analysis of Results: The main outcome measures included the rate and number of euploid blastocysts and their correlation with ovarian reserve. Our results showed a statistically significant association between independent variables and embryo ploidy: AMH levels (OR 1.09; 95% CI 1.04-1.14, p<0.001), the age of the woman (OR 0.82; 95% CI 0.79-0.85, p<0.001), the number of oocytes retrieved (OR 1.050; 95% CI 1.01-1.08, p=0.05), and the fertilization rate (OR 6.69; 95% CI 2.67-16.77, p<0.001). Conclusion: Our findings suggest that AMH levels are associated with embryo ploidy rate. These insights could enhance counseling practices in assisted reproductive technology (ART), offering patients a more detailed understanding of their infertility prognosis and the factors influencing IVF outcomes.

Indexed as

AneuploidyInfertility, FemaleOvarian ReserveAdultAnti-Mullerian HormoneFemaleFertilization in VitroHumansPregnancyPreimplantation DiagnosisRetrospective StudiesAnti-Mullerian HormoneAMHassisted reproduction (ART)diminished ovarian reserve (DOR)embryo ploidy ratePGT-A

Identifiers

PMID39897960
PMCPMC11783844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.