Evidence map›Paper›PMID 39897830›Full record

ArticleHeliyon2025

Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility.

Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K Stine V Bagge, Jennifer R Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D Hickson, Andrés López-Contreras, Michael Lisby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ernest Wee Kiat LimSection for Functional Genomics, Department of Biology University of Copenhagen, 2200, Copenhagen N, Denmark.
Smaragda KompocholiSection for Functional Genomics, Department of Biology University of Copenhagen, 2200, Copenhagen N, Denmark.
André BrannvollSection for Functional Genomics, Department of Biology University of Copenhagen, 2200, Copenhagen N, Denmark.
K Stine V BaggeSection for Functional Genomics, Department of Biology University of Copenhagen, 2200, Copenhagen N, Denmark.
Jennifer R GruhnCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200, Copenhagen N, Denmark.
Javier Martin-GonzalezCore Facility for Transgenic Mice, Department of Experimental Medicine, University of Copenhagen, 2200, Copenhagen N, Denmark.
Eliene AlbersCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200, Copenhagen N, Denmark.
Ian D HicksonCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200, Copenhagen N, Denmark.
Andrés López-ContrerasCenter for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200, Copenhagen N, Denmark.
Michael LisbySection for Functional Genomics, Department of Biology University of Copenhagen, 2200, Copenhagen N, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently characterised human ZGRF1 helicase promotes genomic stability by facilitating DNA interstrand crosslink repair. In its absence, human cells exhibit greater sensitivity towards anti-cancer drugs such as mitomycin C and camptothecin. Moreover, the downregulation of

Indexed as

DNA helicaseDNA repairHomologous recombinationInterstrand crosslinksMouse modelZGRF1

Identifiers

PMID39897830
PMCPMC11787654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.