Evidence map›Paper›PMID 39897554›Full record

ArticleTheranostics2025

Glutamatergic pathways from medial prefrontal cortex to paraventricular nucleus of thalamus contribute to the methamphetamine-induced conditioned place preference without affecting wakefulness.

Xiang Li, Xing Xu, Quying Feng, Ning Zhou, Yuhong He, Ying Liu, Haoqing Tai, Hee Young Kim, Yu Fan, Xiaowei Guan

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiang LiDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Xing XuDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Quying FengDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ning ZhouDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yuhong HeDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ying LiuDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Haoqing TaiDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Hee Young KimDepartment of Physiology, Yonsei University College of Medicine, Seoul, South Korea.
Yu FanDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Xiaowei GuanDepartment of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing 210023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine (METH) is a commonly abused psychostimulant with a high addictive nature. The paraventricular nucleus of thalamus (PVT), a key nucleus for arousal, has attracted much attention in the reward process of substance use. However, at which stage dose the PVT encode the reward process? How to reduce the side-effects of modulating PVT on wakefulness during the treatment of substance use? These issues remain unclear. The goal of the current study is to explore the role of the PVT and the glutamatergic projections from medial prefrontal cortex (mPFC) to PVT in the reward process of METH.

Indexed as

Glutamic AcidMethamphetamineMidline Thalamic NucleiPrefrontal CortexWakefulnessAnimalsCentral Nervous System StimulantsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsRewardCentral Nervous System StimulantsGlutamic AcidMethamphetamineGluN2AMETHmPFC-PVT glutamatergic pathwayPVTwakefulness

Identifiers

PMID39897554
PMCPMC11780515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.