Evidence map›Paper›PMID 39897539›Full record

ArticleRegenerative biomaterials2025

pH-responsive hydrogel with dual-crosslinked network of polyvinyl alcohol/boric acid for controlled release of salvianolic acid B: novel pro-regenerative mechanisms in scar inhibition and wound healing.

Wei Song, Chao Zhang, Zhao Li, Kejia Li, Yi Kong, Jinpeng Du, Yue Kong, Xu Guo, Xiaoyan Ju, Meng Zhu and 3 more

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  12. Gelatin/hyaluronic acid-basedRegenerative biomaterials · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei SongKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Chao ZhangMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.ORCID https://orcid.org/0000-0002-1117-0991
Zhao LiMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.
Kejia LiKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yi KongMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.
Jinpeng DuMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.
Yue KongMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.
Xu GuoMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.
Xiaoyan JuKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Meng ZhuKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Ye TianKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Sha HuangMedical Innovation Research Department, Research Center for Wound Repair and Tissue Regeneration, Chinese PLA General Hospital, Beijing 100048, China.ORCID https://orcid.org/0000-0001-8868-2680
Zhongwei NiuKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates a novel pH-responsive hydrogel composed of polyvinyl alcohol (PVA) and boric acid (BA) designed for the controlled release of salvianolic acid B (SAB), addressing the critical challenge of scar formation and skin regeneration. The dual-crosslinked network architecture of the hydrogel exhibits remarkable pH sensitivity, enabling it to achieve a peak SAB release within 48 hours in the acidic microenvironment characteristic of early-stage wound healing.

Indexed as

controlled releasedual-crosslinked networksalvianolic acid Bscar inhibitionskin regeneration

Identifiers

PMID39897539
PMCPMC11785367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.