Single centre retrospective review of plasma branched-chain amino acid levels in children with urea cycle disorders: Impact of treatment modalities and disease severity.

Mildrid Yeo, Preeya Rehsi, Jie Ming Yeo, Marjorie Dixon, Anupam Chakrapani

Abstract read

In one paragraph

Article in Molecular genetics and metabolism reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Pre-emptive treatment in later-onset urea cycle disorders: a clinical perspective on glycerol phenylbutyrate.Orphanet journal of rare diseases · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mildrid YeoDepartment of Paediatric Inherited Metabolic Disease, Great Ormond Street Hospital for Children, NHS Foundation Trust and Institute for Child Health, London, UK.

Preeya RehsiDepartment of Paediatric Inherited Metabolic Disease, Great Ormond Street Hospital for Children, NHS Foundation Trust and Institute for Child Health, London, UK.

Jie Ming YeoDepartment of Paediatric Inherited Metabolic Disease, Great Ormond Street Hospital for Children, NHS Foundation Trust and Institute for Child Health, London, UK.

Marjorie DixonDietetics, Great Ormond Street Hospital for Children, NHS Foundation Trust and Institute for Child Health, London, UK.

Anupam ChakrapaniDepartment of Paediatric Inherited Metabolic Disease, Great Ormond Street Hospital for Children, NHS Foundation Trust and Institute for Child Health, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Branched-chain amino acids (BCAAs) are important for normal growth, development, and function. In urea cycle disorders (UCDs), plasma BCAA levels can be relatively low; this has been attributed variously to low protein intake, hyperammonaemia, and nitrogen scavenger treatment. We undertook a retrospective review of plasma BCAA levels in individuals with UCDs comprising ornithine carbamoyltransferase deficiency (OTCD

Indexed as

Branched chain amino acidsGlycerol phenylbutyrateNitrogen scavengersSodium benzoateSodium phenylbutyrateUrea cycle disorders

Identifiers

PMID39897473

DOI10.1016/j.ymgmr.2025.101190

PMCPMC11786853

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.