ReviewCureus2025
Risk Factors Associated With Osteonecrosis of the Femoral Head in Patients With Sickle Cell Disease: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Distribution of early- versus late-stage ONFH in core decompression cases at a tertiary center: does presenting symptomatology affect conversion to total hip replacement?Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteonecrosis of the femoral head (ONFH) is a serious complication in patients with sickle cell disease (SCD), secondary to the peculiar pathophysiology of the disease. SCD is characterized by stiff and adhesive RBCs, disturbing blood circulation, and causing ischemia and microvascular damage. Understanding the key risk factors contributing to ONFH in this population is critical for developing targeted interventions to improve outcomes in this population. This study aimed to identify and analyze the key risk factors associated with osteonecrosis of the femoral head (ONFH) in patients with sickle cell disease (SCD) through a comprehensive systematic review and meta-analysis. This meta-analysis used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) tool to search and select the most relevant studies from electronic databases, like Web of Science, Google Scholar, PubMed, Cochrane Library, Embase, and MEDLINE, based on the study focus. The following medical phrases were used in the search: femoral head, aseptic necrosis, osteonecrosis, predictor, risk factor, and sickle cell disease. The study included six studies with a total of 581 participants. Four significant risk factors for ONFH in SCD were identified as follows: genotype (risk ratio: 1.09, 95% CI: 0.94-1.27), elevated hemoglobin levels (mean difference: 0.30, 95% CI: -0.03 to -0.63), hip pain (risk ratio: 1.11, 95% CI: 0.80-1.55), and acute chest pain (mean difference: 1.17, 95% CI: 0.87-1.47). Statistical analysis showed low heterogeneity across studies (I²: 0%, p < 0.05), indicating consistent findings. The ONFH group was more significantly affected by these factors than the comparator group. The meta-analysis revealed an intricate interplay of vascular, hematologic, and systemic factors contributing to ONFH of SCD with the four significant risk factors mainly genotype, elevated hemoglobin levels, hip pain, and acute chest pain. Therefore, it is important to carry out regular check-ups and focus on specific treatments to manage these clearly identified risk factors, which can help slow down the progression of the disease.
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