ArticleCureus2025
Curcumin as a Modulator of Osteogenic Potential in Lipopolysaccharide-Treated Human Periodontal Ligament Cells: An In Vitro Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Curcumin-based smart responsive hydrogels: A controlled release system for bone defect regeneration.Regenerative therapy · 2026Review
- Progesterone-induced activation of progesterone receptor alleviates alveolar bone resorption and inflammatory response in periodontitis.Clinical oral investigations · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Periodontal diseases cause alveolar bone destruction driven by anaerobic bacteria. Their virulence factors disrupt the osteogenic potential of human periodontal ligament stem cells (hPDLCs). Curcumin, a polyphenol with anti-inflammatory and osteogenic properties, holds promise for periodontal regeneration Aim This study evaluated the effects of curcumin on the osteogenic potential of hPDLCs under LPS-induced inflammatory conditions by assessing the expression of osteogenic markers, bone morphogenetic protein-2 (BMP-2), and osteopontin (OPN). Materials and methods hPDLCs were isolated from premolars and cultured in the presence of LPS (10 µg/mL) to simulate inflammation. Cells were treated with curcumin at 2.5 µM and 5 µM, with and without LPS exposure. Gene expression of BMP-2 and OPN was quantified using qRT-PCR after 21 days of culture. Results LPS significantly suppressed BMP-2 and OPN expression (
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