ArticleClinical, cosmetic and investigational dermatology2025
Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Ultra-High-Frequency Ultrasound of Melanoma Excision Scars for Detection of Clinically Occult Local Recurrence: A Single-Center Retrospective Study.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Malignant melanoma (MM) is an extremely aggressive type of skin cancer that represents a major risk to human health. Earlier observational research has indicated that skin microbiota could play a role in the development and advancement of MM. Nevertheless, the causal link between skin microbiota and MM is still unclear. Methods: Utilizing data from genome-wide association studies (GWAS) conducted on a European cohort, we applied Mendelian randomization (MR) to evaluate the causal link between skin microbiota and MM. The analysis involved various MR methodologies, including inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple mode. Furthermore, we performed sensitivity analysis employing the intercept test of MR-Egger, the Cochran's Q test, the MR-PRESSO approach, and a leave-one-out method. Results: By conducting MR analysis on the KORA FF4 cohort, we identified several skin microbiotas (ASV003 [Staphylococcus (unc).], ASV016 [Enhydrobacter (unc).], and ASV021 [Micrococcus (unc).]) related with an elevated risk of MM. Conversely, genus: Finegoldia and class: Alphaproteobacteria were shown to inhibit the occurrence of MM. Additionally, MR analysis of the PopGen cohort revealed that ASV021 [Micrococcus (unc).] and family: Moraxellaceae were identified as possible risk factors for MM. Conclusion: Our research offers new insights into the connection between skin microbiota and MM, indicating that skin microbiota might affect the onset and advancement of MM. Therefore, focusing on skin microbiota could be a valuable strategy for the prevention, identification, and management of MM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.