Evidence map›Paper›PMID 39897069›Full record

ArticleSovremennye tekhnologii v meditsine2024

Efficacy of Poly-3-Hydroxybutyrate Enriched with Simvastatin in Bone Regeneration after Tooth Extraction (Experimental Study).

K M Salekh, A A Muraev, A A Dolgalev, A B Dymnikov, G A Bonartseva, T K Makhina, D V Chesnokova, V V Voinova, A P Bonartsev, M E Mokrenko and 1 more

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Article in Sovremennye tekhnologii v meditsine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

K M SalekhPhD Student, Department of Maxillofacial Surgery and Surgical Dentistry; The Patrice Lumumba Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
A A MuraevMD, DSc, Professor, Department of Maxillofacial Surgery and Surgical Dentistry; The Patrice Lumumba Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
A A DolgalevMD, DSc, Professor, Department of Dentistry of General Practice; Stavropol State Medical University, 310 Mira St., Stavropol, 355017, Russia.
A B DymnikovMD, PhD, Associate Professor, Department of Maxillofacial Surgery and Surgical Dentistry; The Patrice Lumumba Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
G A BonartsevaPhD, Senior Researcher, A.N. Bakh Institute of Biochemistry; Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, 33/2 Leninsky Prospekt, Moscow, 119071, Russia.
T K MakhinaResearcher, A.N. Bakh Institute of Biochemistry; Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, 33/2 Leninsky Prospekt, Moscow, 119071, Russia.
D V ChesnokovaJunior Researcher, Department of Bioengineering, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119234, Russia.
V V VoinovaPhD, Senior Researcher, Department of Bioengineering, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119234, Russia.
A P BonartsevDSc, Associate Professor, Department of Bioengineering, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119234, Russia.
M E MokrenkoPhD Student, Department of Maxillofacial Surgery and Surgical Dentistry; The Patrice Lumumba Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
S Y IvanovMD, DSc, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Maxillofacial Surgery and Surgical Dentistry; The Patrice Lumumba Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia; Head of the Department of Maxillofacial Surgery; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physiological resorption of bone tissue after tooth extraction leads to a decrease in the volume of bone tissue available for implantation and makes it difficult to install dental implants. Preservation of the well after tooth extraction is the solution to this problem, with the choice of bone plastic material playing an important role. The development of an "ideal" bone plastic material with osteoinductive properties that promotes reparative bone regeneration remains an urgent task. Materials and Methods: The study was conducted on 24 adult sheep with a total of 48 teeth removed. 12 wells were filled with material based on poly(3-hydroxybutyrate) (PHB) with simvastatin; 12 wells were filled with PHB-based material without simvastatin, 24 wells were used as a control. Micro-CT was used for comparative analysis of bone tissue formation between the test groups after 3 and 6 months. Results: The results of the study confirm the positive effect of simvastatin released from the PHB-based osteoplastic material on the volume of the formed bone tissue and the total bone volume in the defect area (BV/TV) and bone mineral density (BMD) 3 and 6 months after surgery. Conclusion: The study demonstrated that simvastatin, released from the PHB-based osteoplastic material, has an osteoinductive effect, promoting bone tissue regeneration in the wells left after tooth removal. Higher BV/TV and BMD values in the wells indicate better efficacy of the material in terms of regeneration support.

Indexed as

Bone RegenerationHydroxybutyratesPolyestersSimvastatinTooth ExtractionX-Ray MicrotomographyAnimalsBone SubstitutesPolyhydroxybutyratesSheepBone SubstitutesHydroxybutyratespoly-beta-hydroxybutyratePolyestersPolyhydroxybutyratesSimvastatinbone plastic materialosteoinductionpoly(3-hydroxybutyrate)porous microspherespostextraction preservationreparative osteogenesissimvastatin

Identifiers

PMID39897069
PMCPMC11784884

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.