Evidence map›Paper›PMID 39896978›Full record

ArticleMaterials today. Bio2025

Photothermal-enhanced silver nanocluster bioactive glass hydrogels for synergistic antimicrobial and promote wound healing.

Fuqiang Song, Anqi Ye, Linyuan Jiang, Yang Lu, Yanzhen Feng, Rong Huang, Siting Du, Xiaoyu Dong, Ting Huang, Ping Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Electromagnetic-Thermal Coupling Competition in Ag@TiONanomaterials (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fuqiang SongAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Anqi YeAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Linyuan JiangAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Yang LuDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Yanzhen FengDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Rong HuangAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Siting DuDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Xiaoyu DongDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Ting HuangDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Ping LiDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Liangliang YangAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Jinjing ZhangAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Mengjia XuNingbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Li ChengAffiliated Cixi Hospital, Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China.
Jian XiaoDepartment of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibacterial hydrogels are promising for combating infections and promoting wound healing. Nevertheless, excessive antibiotics induce resistance, and high metal ion levels cause cytotoxicity, complicating healing. Here, we introduce a hydrogel incorporating polydopamine-coated bioactive glass (BGs@PDA) on reduced graphene oxide (rGO) with photothermal therapy (PTT) and silver nanoclusters (AgNCs) for synergistic antibacterial treatment. This design enables rapid bacterial eradication and controlled release. Near-infrared-assisted heating provides noninvasive, targeted hyperthermia, killing bacteria quickly. Post-PTT addition of low-dose AgNCs reduces toxicity while enhancing antimicrobial efficacy and biocompatibility. BGs@PDA-loaded rGO prevents sedimentation, improves photothermal conversion and conductivity, and stabilizes the hydrogel structure. Constructed from chitosan and hydroxyethyl cellulose, the hydrogel is cross-linked by PDA and rGO, enhancing mechanical strength, adhesion, self-healing, free radical scavenging, and continuous wound exudate absorption. PDA encapsulation facilitates BGs degradation, improving the wound microenvironment. In vivo studies confirm accelerated healing and potent synergistic antibacterial effects, indicating its potential as a low-dose, antibiotic-free alternative for clinical wound infection management.

Indexed as

Antibacterial hydrogelsPhotothermal antibacterialPolydopamine-coated bioactive glassSilver nanohybridsWound healing

Identifiers

PMID39896978
PMCPMC11785576

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.