ArticleCureus2025
Memory-Enhancing and Anxiolytic Effects of the Rose of Jericho on Sleep Deprivation-Related Cognitive and Behavioral Changes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSleep is a crucial physiological phenomenon that enables the body to engage in restoration and rejuvenation. Remarkably, even limited periods of sleep deprivation (SD) can adversely affect cognitive functions such as memory retention, emotional regulation, data processing, and concentration. The Rose of Jericho (RoJ) has been considered more than a plant and has demonstrated potential therapeutic actions in childbirth, respiratory diseases, gastrointestinal disorders, and cancer. The effect of the RoJ on memory, cognition, and behavior has not yet been well-studied.
objectivesThe present study aimed to investigate the possible therapeutic effects of the RoJ on memory, cognition, behavior, and motor coordination in a rat model of SD. MATERIALS AND
methodsThirty male Wistar albino rats weighing 120-150 g were used in the present study. The rats were acclimatized and trained and then randomly divided into three groups: control (C), sleep-deprived (SD), and SD treated with RoJ (SD+RoJ). Spatial memory and learning were assessed using the Morris Water Maze (MWM) test, while anxiety-related behaviors were evaluated through the Elevated Plus Maze (EPM) test. The rotarod test was used to assess motor coordination.
resultsThe study revealed significant behavioral and cognitive performance improvements with the SD+RoJ group across all the tests. In the MWM test, the SD group exhibited a marked increase in test duration (29.5 ± 3.57 sec) and a reduction in average speed (1.9 ± 0.3 cm/s) when compared to the C group (13.41 ± 1.57 sec and 5.9 ± 0.34 cm/s, respectively). Interestingly, the SD+RoJ group significantly reduced test duration (19.75 ± 3.36 sec) and improved rats' speed (6.06 ± 0.27 cm/s) compared to the SD group. The EPM test demonstrated that the SD group spent significantly less time in the open arms (16.2 ± 9.44 sec) than the C group (59.8 ± 3.29 sec). Interestingly, the SD+RoJ group significantly improved the time spent in the open arms (45.8 ± 11.64 sec). Moreover, the SD+RoJ group showed notable improvement in open-arm entries (7 ± 2.39) compared to the SD group (1.6 ± 0.81). In the Rotarod test, the SD group demonstrated a significant decline in latency to fall (44.2 ± 9.5 sec) compared to the C group (228.67 ± 35.44 sec). The SD+RoJ group exhibited a significantly longer falling latency (165 ± 28.77 sec) than the SD group.
conclusionTreatment with the RoJ alleviated SD-dependent cognitive impairment, anxiety, and decline in motor coordination. Supplementation with the RoJ may offer potential therapeutic benefits, including boosting memory, improving cognition, reducing anxiety and depression, and enhancing motor coordination.
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