ArticleFrontiers in immunology2024
Aspartate aminotransferase to platelet ratio correlates with poor prognosis and metabolic alterations in
Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- NLPR as a predictor of poor prognosis in patients with severe fever with thrombocytopenia syndrome: a prospective longitudinal study.Frontiers in cellular and infection microbiology · 2026Article
- Association of TyG with Survival and Metabolic Alterations in Severe Fever with Thrombocytopenia Syndrome: A Single- Centre Retrospective Study.Infection and drug resistance · 2026Article
- Predicting mortality risk of severe fever with thrombocytopenia syndrome: A multi-center retrospective cohort study.Virologica Sinica · 2025Article
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4 authors.
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Abstract
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate caused by Methods: Data from hospitalized patients with a confirmed diagnosis of SFTS virus infection at Wuhan Union Hospital were retrospectively collected. The low and high APRI groups were 1:1 matched using propensity score matching (PSM) analysis. Fresh plasma was collected from patients with SFTS on admission and used for metabolic tests. Results: A total of 617 patients with SFTS who met the inclusion criteria were selected for analysis. Survival analysis revealed that patients with SFTS with high APRI (> 35.3) had a substantially higher death rate than those with low APRI (≤ 35.3). Receiver operating characteristic analysis showed the predictive performance of APRI for SFTS prognosis is 0.77, with a 95% CI of 0.73-0.80, which was superior to NLR (area under the curve (AUC): 0.65), platelet-to-lymphocyte ratio (AUC: 0.54), and systemic immune-inflammation index (AUC: 0.58). The prognostic value and predictive performance of APRI were more substantial after PSM than before PSM. Metabolomic testing identified several differential serum metabolites, with alanine, aspartate, glutamate, glycerophospholipid, and tryptophan metabolism being the most important metabolic pathways. Conclusion: A high APRI score was associated with relatively higher mortality in patients with SFTS, and its predictive performance for the survival outcome of SFTS was superior to that of well-recognized inflammatory scores. Alanine, aspartate, and glutamate metabolism are involved in the progression of SFTS.
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